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NMI-TfCl 介导的酰胺键形成在使用较少碱性（杂）芳基胺合成生物相关的噁二唑衍生物中的应用。

Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines.

机构信息

Department of Chemistry, SSIT, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, 572107, India.

College of Natural and Health Sciences, Zayed University, PO Box 144534, Khalifa City, Abu Dhabi, UAE.

出版信息

Mol Divers. 2022 Jun;26(3):1761-1767. doi: 10.1007/s11030-021-10275-7. Epub 2021 Jul 22.

DOI:10.1007/s11030-021-10275-7
PMID:34296385
Abstract

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage.

摘要

本文报道了一种在温和条件下合成一些与酰胺键相连的恶二唑的改良方法。研究发现，使用 NMI-TfCl 的开发方案对一系列电子去活化和空间位阻较大的胺的酰胺键形成反应具有有效性和耐受性。在后期阶段评估了新合成化合物的抗氧化潜力。

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