Li Laiqiang, Hou Zhong-Wei, Li Pinhua, Wang Lei
Advanced Research Institute and Department of Chemistry Taizhou University, Taizhou 318000, P.R. China.
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China.
Org Lett. 2021 Aug 6;23(15):5983-5987. doi: 10.1021/acs.orglett.1c02063. Epub 2021 Jul 23.
An electrochemical approach for the site-selective C-H cyanation of indoles employing readily available TMSCN as cyano source has been developed. The electrosynthesis relies on the tris(4-bromophenyl)amine as a redox catalyst, which achieves better yield and regioselectivity. A variety of C2- and C3-cyanated indoles were obtained in satisfactory yields. The reactions are conducted in a simple undivided cell at room temperature and obviate the need for transition-metal reagent and chemical oxidant.
已开发出一种电化学方法，用于以易于获得的TMSCN作为氰基源对吲哚进行位点选择性C-H氰化反应。该电合成依赖于三(4-溴苯基)胺作为氧化还原催化剂，可实现更好的产率和区域选择性。以令人满意的产率获得了多种C2-和C3-氰化吲哚。反应在室温下于简单的无隔膜电解池中进行，无需过渡金属试剂和化学氧化剂。
