School of Chemistry and Materials Engineering, Huizhou University, Huizhou, 516007, Guangdong, China.
Org Biomol Chem. 2020 Aug 21;18(31):6108-6114. doi: 10.1039/d0ob00485e. Epub 2020 Jul 31.
The ligand-free palladium-catalyzed C3-cyanation of indoles via direct C-H functionalization was achieved. This protocol, utilizing CHCN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C-CN bond cleavage.
通过直接 C-H 功能化实现了无配体钯催化吲哚的 C3 氰化反应。该方案利用 CHCN 作为绿色且易得的氰源，通过过渡金属催化的 C-CN 键断裂，以中等至良好的收率得到所需产物。
