From the Department of Clinical Sciences and Molecular, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607.
From the Department of Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607.
Am J Vet Res. 2021 Aug;82(8):629-633. doi: 10.2460/ajvr.82.8.629.
To use CT-derived measurements to calculate a shape constant (K constant) and create a formula to calculate body surface area (BSA) on the basis of body weight in bearded dragons ().
12 adult client-owned bearded dragons that underwent CT between December 4, 2019, and April 2, 2020.
Each bearded dragon in this prospective cohort study underwent physical examination, body weight measurement, and CT. A 3-D surface model was then reconstructed from CT data with available software and used for BSA calculations. Animals were considered collectively and grouped by sex and age. Nonlinear regression analysis of BSA versus body weight was performed, and a species-specific formula was derived for calculating BSA in bearded dragons.
Mean age, body weight, and CT-derived BSA were 2.1 years, 356 g, and 580 cm. The calculated K constant was 11.6 ( = 0.994; SE = 0.275) for the 12 bearded dragons, and the CT-derived BSA formula was as follows: BSA in cm = 11.6 × (body weight in g). The K constant differed substantially for bearded dragons grouped by age (12.1 for younger [between 1 and ≤ 2 years of age; n = 8] vs 10.9 for older [> 2 years of age; 4] animals) but did not differ on the basis of sex.
Results indicated that because the K constant for bearded dragons in the present study was larger than the preexisting K constant of 10 used for reptiles or the various K constants established for some companion mammals, doses of chemotherapeutic drugs needed to treat affected bearded dragons may be higher than previously thought.
利用 CT 衍生的测量值计算形状常数（K 常数），并基于体重创建一个计算公式来计算鬃狮蜥的体表面积（BSA）。
2019 年 12 月 4 日至 2020 年 4 月 2 日期间接受 CT 检查的 12 只成年客户所有的鬃狮蜥。
本前瞻性队列研究中的每只鬃狮蜥均接受了体格检查、体重测量和 CT 检查。然后，使用可用软件从 CT 数据中重建 3D 表面模型，并用于 BSA 计算。将动物集体分组，按性别和年龄分组。对 BSA 与体重进行非线性回归分析，并得出计算鬃狮蜥 BSA 的种特异性公式。
平均年龄、体重和 CT 衍生的 BSA 分别为 2.1 岁、356 克和 580 厘米。12 只鬃狮蜥的计算 K 常数为 11.6（=0.994；SE=0.275），CT 衍生的 BSA 公式如下：BSA 厘米=11.6×（体重克）。按年龄分组的 K 常数差异较大（1 岁至≤2 岁的年幼组为 12.1，>2 岁的年长组为 10.9），但按性别分组无差异。
结果表明，由于本研究中鬃狮蜥的 K 常数大于先前用于爬行动物的 10 常数或为某些伴侣动物建立的各种 K 常数，因此治疗受影响鬃狮蜥所需的化疗药物剂量可能高于先前认为的剂量。
