College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Exotic Species Cancer Research Alliance, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Am J Vet Res. 2023 Aug 28;84(11). doi: 10.2460/ajvr.23.06.0131. Print 2023 Nov 1.
To use CT measurements to define the body surface area (BSA) formula in American bullfrogs (Lithobates catesbeianus) and calculate the species-specific shape constant (K) to suggest chemotherapeutic doses.
12 American bullfrogs owned by the North Carolina State College of Veterinary Medicine Department of Laboratory Animal Resources underwent CT scans without anesthesia or sedation in November 2022.
As part of this prospective study, each American bullfrog underwent a complete physical exam and CT scan. 3-D surface models were created using CT data, and the resulting measurements were used for BSA calculations. Animals were grouped by sex. Nonlinear regression analysis of BSA versus body weight was performed, and a species-specific formula was derived for calculating BSA in American bullfrogs.
The mean body weight of the bullfrogs was 354 grams. The mean CT-derived BSA was 414.92 cm2. The calculated K constant was 8.28 for the 12 American bullfrogs, and the CT-derived BSA formula was BSA in cm2 = 8.28 X (body weight in g)2/3. The K constant was 8.07 for females and 8.44 for males and was not significantly different between sexes (P = .5).
Results indicated that the species-specific K constant for American bullfrogs is 8.28. This is the first calculated K constant that exists for amphibians to our knowledge.
使用 CT 测量值定义美洲牛蛙（Lithobates catesbeianus）的体表面积（BSA）公式，并计算物种特异性形状常数（K），以建议化疗剂量。
2022 年 11 月，北卡罗来纳州立兽医学院实验动物资源部的 12 只美洲牛蛙在未接受麻醉或镇静的情况下进行了 CT 扫描。
作为这项前瞻性研究的一部分，每只美洲牛蛙都接受了全面的身体检查和 CT 扫描。使用 CT 数据创建 3-D 表面模型，并使用所得测量值进行 BSA 计算。动物按性别分组。对 BSA 与体重的关系进行非线性回归分析，并得出用于计算美洲牛蛙 BSA 的物种特异性公式。
牛蛙的平均体重为 354 克。平均 CT 衍生 BSA 为 414.92 cm2。计算得出的 12 只美洲牛蛙的 K 常数为 8.28，CT 衍生 BSA 公式为 BSA in cm2 = 8.28 X (body weight in g)2/3。雌性的 K 常数为 8.07，雄性为 8.44，性别之间无显著差异（P =.5）。
结果表明，美洲牛蛙的物种特异性 K 常数为 8.28。据我们所知，这是第一个为两栖动物计算的 K 常数。
