Dilsaver S C, Snider R M
Department of Psychiatry, University of Michigan, Ann Arbor.
J Clin Psychopharmacol. 1987 Dec;7(6):410-3.
The discontinuation of tricyclic antidepressants (TCAs) can produce symptoms suggesting cholinergic overdrive. The authors previously proposed that these withdrawal states are the consequence of TCA affected cholinergic system supersensitivity. Evidence that chronic treatment with amitriptyline produces dose-dependent supersensitization of a central cholinergic mechanism is now presented. Core temperature is subject to a hypothalamic muscarinic mechanism. The thermic response of adult male rats to oxotremorine was telemetrically measured after 7 days of treatment with saline or amitriptyline 3, 10, and 20 mg/kg given intraperitoneally twice daily. Treatment with the TCA produced dose-dependent enhancement of oxotremorine-induced hypothermia. The data support the hypothesis that at least some TCA withdrawal phenomena involves supersensitization of muscarinic systems.
停用三环类抗抑郁药（TCA）可产生提示胆碱能亢进的症状。作者此前提出，这些戒断状态是TCA影响胆碱能系统超敏反应的结果。现在有证据表明，阿米替林的长期治疗会产生中枢胆碱能机制的剂量依赖性超敏反应。核心体温受下丘脑毒蕈碱机制的影响。成年雄性大鼠腹腔注射生理盐水或3、10和20mg/kg阿米替林，每日两次，连续7天后，通过遥测法测量其对氧化震颤素的热反应。TCA治疗产生了氧化震颤素诱导的体温过低的剂量依赖性增强。这些数据支持了这样的假设，即至少一些TCA戒断现象涉及毒蕈碱系统的超敏反应。
