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阿米替林诱导的中枢毒蕈碱机制超敏反应：锂可阻断阿米替林诱导的超敏反应。

Amitriptyline-induced supersensitivity of a central muscarinic mechanism: lithium blocks amitriptyline-induced supersensitivity.

作者信息

Dilsaver S C, Hariharan M

机构信息

Department of Psychiatry and Neuroscience, Ohio State University, Columbus 43210-1228.

出版信息

Psychiatry Res. 1988 Aug;25(2):181-6. doi: 10.1016/0165-1781(88)90049-2.

DOI:10.1016/0165-1781(88)90049-2
PMID:2845459
Abstract

Chronic treatment with amitriptyline produces dose-dependent super-sensitivity of a central muscarinic cholinergic mechanism involved in the regulation of core body temperature. The authors demonstrated that chronic treatment with lithium prevents the induction of this response. The potential clinical and theoretical significance of this finding is set forth.

摘要

阿米替林的长期治疗会使参与调节核心体温的中枢毒蕈碱胆碱能机制产生剂量依赖性超敏反应。作者证明，锂盐的长期治疗可防止这种反应的诱导。阐述了这一发现的潜在临床和理论意义。

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