音量控制：调节调节性 T 细胞。

Volume control: Turning the dial on regulatory T cells.

机构信息

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Department of Immunology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Cell. 2021 Jul 22;184(15):3847-3849. doi: 10.1016/j.cell.2021.06.015.

DOI:10.1016/j.cell.2021.06.015

PMID:34297928

Abstract

Treg-mediated immunosuppression must be tightly regulated to support immunity while limiting tissue damage. In this issue of Cell, Wong et al. and Marangoni et al. use high-resolution imaging to define feedback circuits that quantitatively control local Treg expansion and function.

摘要

调节性 T 细胞（Treg）介导的免疫抑制作用必须受到严格调控，既要支持免疫，又要限制组织损伤。在本期《细胞》杂志上，Wong 等人和 Marangoni 等人利用高分辨率成像技术定义了反馈回路，可定量控制局部 Treg 的扩增和功能。