Jegorova N B, Výmola F, Jefremova V N, Vrbová E
I. I. Metehnikov Research Institute of Vaccines and Sera, USSR.
J Hyg Epidemiol Microbiol Immunol. 1987;31(4):445-52.
A comparative experimental study was carried out of antigenic staphylococcal preparations developed in the USSR and Czechoslovakia for the immune therapy of chronic staphylococcal infection. The efficiency of the preparations was unequivocally confirmed using the rabbit staphylococcal sepsis model. The immunogenicity of tested strains was shown not to always correlate with their virulence. Preparations obtained by means of aqueous extraction from mildly virulent immunogenic strains exhibited greater protective activity than those prepared from highly virulent strains. The PCA phenomenon did not differ significantly provided the tested preparations were administered at doses which ensured equal protective action.
对苏联和捷克斯洛伐克研制的用于慢性葡萄球菌感染免疫治疗的抗原性葡萄球菌制剂进行了一项对比实验研究。使用兔葡萄球菌败血症模型明确证实了这些制剂的有效性。结果表明，受试菌株的免疫原性并不总是与其毒力相关。从轻度毒力的免疫原性菌株通过水提取法获得的制剂比从高毒力菌株制备的制剂具有更强的保护活性。如果以确保同等保护作用的剂量施用受试制剂，PCA现象没有显著差异。
