Efremova V N, Egorova N B
Zh Mikrobiol Epidemiol Immunobiol. 1978(12):59-63.
The toxicity and the protective activity of a complex staphyloccus antigen was studied. Its insignificant toxicity for mice when injected intraperitoneally and protective activity under conditons of experimental infection on mice, rabbits, and guinea pigs were demonstrated. In particular it was shown that the antigen obtained in doses under study protected rabbits from septic staphylococcus infection more than antitoxin and corpuscular vaccine. Under conditons of local experimental infection on mice the complex antigen promoted a more rapid than corpuscular vaccine elimination of the local focus of infection.
对一种复合葡萄球菌抗原的毒性和保护活性进行了研究。结果表明，腹腔注射时该抗原对小鼠的毒性不显著，且在小鼠、兔子和豚鼠的实验感染条件下具有保护活性。特别值得指出的是，在所研究剂量下获得的该抗原对兔子败血性葡萄球菌感染的保护作用比抗毒素和微粒疫苗更强。在小鼠局部实验感染条件下，复合抗原比微粒疫苗能更快速地清除局部感染病灶。
