Radanova Maria, Mihaylova Galya, Nazifova-Tasinova Neshe, Levkova Mariya, Tasinov Oskan, Ivanova Desislava, Mihaylova Zhasmina, Donev Ivan
Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.
Laboratory of Molecular Pathology, University Hospital "St. Marina", 9000 Varna, Bulgaria.
Cancers (Basel). 2021 Jul 6;13(14):3395. doi: 10.3390/cancers13143395.
Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients.
结直肠癌（CRC）在全球范围内是女性中第二常见的诊断疾病，在男性中则排第三。因此，寻找新的、更可靠的生物标志物用于早期诊断、转移预测以及对传统疗法的耐药性预测，是攻克该疾病的一项重大挑战。本综述介绍了环状RNA（circRNAs），其独特特性使其有望成为结直肠癌的预后和诊断生物标志物。该综述强调了具有致癌功能的circRNAs在结直肠癌中的作用机制和作用，以及它们的表达与结直肠癌患者临床病理特征之间的关联。对致癌circRNAs在结直肠癌发病机制中作用的理解正在迅速发展，下一步是将它们作为合适的新药物靶点用于结直肠癌患者的个性化治疗。
