Ameli-Mojarad Mandana, Ameli-Mojarad Melika, Hadizadeh Mahrooyeh, Young Chris, Babini Hosna, Nazemalhosseini-Mojarad Ehsan, Bonab Maziar Ashrafian
Department of Biology, Faculty of Basic Science, Kharrazi University, Tehran, Iran.
School of Medicine, University of Sunderland, City Campus, Chester Road, Sunderland, SR1 3SD, UK.
Cancer Cell Int. 2021 Sep 17;21(1):496. doi: 10.1186/s12935-021-02196-0.
Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC.
结直肠癌（CRC）是全球第三大常见癌症类型。晚期检测导致每年三分之一的CRC死亡率。因此，找到一种精确且最佳的诊断和预后生物标志物对于结直肠肿瘤发生的识别和治疗至关重要。共价闭合环状RNA（circRNAs）是一类非编码RNA，其功能可以与微小RNA（miRNA）海绵相同，作为剪接和转录的调节因子，以及与RNA结合蛋白（RBPs）相互作用。因此，circRNAs已被研究作为CRC诊断和预后检测的特定靶点。这些非编码RNA还与转移、增殖、分化、迁移、血管生成、凋亡和耐药性有关，说明了了解它们在CRC发生发展分子机制中的作用的重要性。在本综述中，我们详细总结了与circRNAs失调及其在CRC中的潜在作用相关的最新研究结果。
