Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Int J Mol Sci. 2021 Jul 14;22(14):7526. doi: 10.3390/ijms22147526.
In the last decades, a kind of small non-coding RNA molecules, called as microRNAs, has been applied as negative regulators in various types of cancer treatment through down-regulation of their targets. More recent studies exert that microRNAs play a critical role in the EMT process of cancer, promoting or inhibiting EMT progression. Interestingly, accumulating evidence suggests that pure compounds from natural plants could modulate deregulated microRNAs to inhibit EMT, resulting in the inhibition of cancer development. This small essay is on the purpose of demonstrating the significance and function of microRNAs in the EMT process as oncogenes and tumor suppressor genes according to studies mainly conducted in the last four years, providing evidence of efficient target therapy. The review also summarizes the drug candidates with the ability to restrain EMT in cancer through microRNA regulation.
在过去的几十年中，一种被称为 microRNA 的小型非编码 RNA 分子已被用作各种类型癌症治疗的负调节剂，通过下调其靶标。最近的研究表明，microRNA 在癌症的 EMT 过程中发挥关键作用，促进或抑制 EMT 的进展。有趣的是，越来越多的证据表明，天然植物中的纯化合物可以调节失调的 microRNA 来抑制 EMT，从而抑制癌症的发展。这篇短文的目的是根据过去四年的主要研究，展示 microRNA 在 EMT 过程中作为癌基因和抑癌基因的意义和功能，为有效的靶向治疗提供证据。该综述还总结了通过 microRNA 调控抑制 EMT 的候选药物。
