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绵羊胎盘转录组对母体营养限制的适应。

Placental Transcriptome Adaptations to Maternal Nutrient Restriction in Sheep.

机构信息

Department of Animal Science, Texas A & M University, College Station, TX 77843, USA.

Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, TX 77843, USA.

出版信息

Int J Mol Sci. 2021 Jul 17;22(14):7654. doi: 10.3390/ijms22147654.

DOI:10.3390/ijms22147654
PMID:34299281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8306922/
Abstract

Placental development is modified in response to maternal nutrient restriction (NR), resulting in a spectrum of fetal growth rates. Pregnant sheep carrying singleton fetuses and fed either 100% ( = 8) or 50% (NR; = 28) of their National Research Council (NRC) recommended intake from days 35-135 of pregnancy were used to elucidate placentome transcriptome alterations at both day 70 and day 135. NR fetuses were further designated into upper (NR NonSGA; = 7) and lower quartiles (NR SGA; = 7) based on day 135 fetal weight. At day 70 of pregnancy, there were 22 genes dysregulated between NR SGA and 100% NRC placentomes, 27 genes between NR NonSGA and 100% NRC placentomes, and 22 genes between NR SGA and NR NonSGA placentomes. These genes mediated molecular functions such as MHC class II protein binding, signaling receptor binding, and cytokine activity. Gene set enrichment analysis (GSEA) revealed significant overrepresentation of genes for natural-killer-cell-mediated cytotoxicity in NR SGA compared to 100% NRC placentomes, and alterations in nutrient utilization pathways between NR SGA and NR NonSGA placentomes at day 70. Results identify novel factors associated with impaired function in SGA placentomes and potential for placentomes from NR NonSGA pregnancies to adapt to nutritional hardship.

摘要

胎盘发育会响应母体营养限制（NR）进行调整，从而导致胎儿生长速度出现一系列变化。本研究利用妊娠绵羊模型，在妊娠第 35-135 天，对单胎绵羊分别给予 100%（=8 只）或 50%（NR；=28 只）的国家研究委员会（NRC）推荐摄入量，以阐明妊娠第 70 天和 135 天胎盘转录组的变化。根据妊娠第 135 天胎儿体重，NR 胎儿进一步被分为上四分位数（NR NonSGA；=7 只）和下四分位数（NR SGA；=7 只）。妊娠第 70 天，NR SGA 与 100%NRC 胎盘之间有 22 个基因表达失调，NR NonSGA 与 100%NRC 胎盘之间有 27 个基因表达失调，NR SGA 与 NR NonSGA 胎盘之间有 22 个基因表达失调。这些基因介导了 MHC Ⅱ类蛋白结合、信号受体结合和细胞因子活性等分子功能。基因集富集分析（GSEA）显示，与 100%NRC 胎盘相比，NR SGA 中与自然杀伤细胞介导的细胞毒性相关的基因显著富集，且 NR SGA 与 NR NonSGA 胎盘之间的营养利用途径在妊娠第 70 天发生改变。结果表明，NR SGA 胎盘功能受损与多种新的因子有关，且 NR NonSGA 妊娠的胎盘可能适应营养困境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3084/8306922/55ca88943715/ijms-22-07654-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3084/8306922/55ca88943715/ijms-22-07654-g008.jpg
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