Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Program Study of Pharmacy, Faculty of Mathematics and Natural Sciences, Bandung Islamic University, Bandung 40116, Indonesia.
Int J Environ Res Public Health. 2021 Jul 6;18(14):7214. doi: 10.3390/ijerph18147214.
Gadolinium (Gd)-based contrast agents (GBCAs) are chemicals injected intravenously during magnetic resonance imaging (MRI) to enhance the diagnostic yield. The repeated use of GBCAs can cause their deposition in the brain, including the cerebellum. Such deposition may affect various cell subsets in the brain and consequently cause behavioral alterations due to neurotoxicity. Caution should thus be exercised in using these agents, particularly in patients who are more likely to have repeated enhanced MRIs during their lifespan. Further studies are required to clarify the toxicity of GBCAs, and potential mechanisms causing neurotoxicity have recently been reported. This review introduces the effects of GBCAs in the cerebellum obtained from in vitro and in vivo studies and considers the possible mechanisms of neurotoxicity involved.
钆（Gd）基对比剂（GBCAs）是在磁共振成像（MRI）期间静脉内注射的化学物质，以提高诊断效果。GBCAs 的重复使用可能导致其在大脑中沉积，包括小脑。这种沉积可能会影响大脑中的各种细胞亚群，并由于神经毒性而导致行为改变。因此，在使用这些药物时应谨慎，特别是在那些一生中更有可能接受重复增强 MRI 的患者中。需要进一步的研究来阐明 GBCAs 的毒性，并且最近已经报道了导致神经毒性的潜在机制。本综述介绍了从体外和体内研究中获得的 GBCAs 在小脑中的作用，并考虑了涉及的神经毒性的可能机制。
