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本文引用的文献

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Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust.两例接触石英岩粉尘工人的多器官进行性矽肺误诊为结节病
Occup Environ Med. 2019 Mar;76(3):178-180. doi: 10.1136/oemed-2018-105462. Epub 2018 Dec 4.
2
Survival following lung transplantation for artificial stone silicosis relative to idiopathic pulmonary fibrosis.人造石矽肺肺移植术后的存活率与特发性肺纤维化相比。
Am J Ind Med. 2017 Mar;60(3):248-254. doi: 10.1002/ajim.22687. Epub 2017 Feb 1.
3
Artificial stone dust-induced functional and inflammatory abnormalities in exposed workers monitored quantitatively by biometrics.通过生物识别技术对接触人工石粉尘工人的功能和炎症异常进行定量监测。
ERJ Open Res. 2016 Mar 17;2(1). doi: 10.1183/23120541.00086-2015. eCollection 2016 Jan.
4
Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports.利用配备波长色散光谱仪的电子探针微分析仪对职业性肉芽肿性肺病进行元素分析：两例报告
Respir Med Case Rep. 2016 Apr 26;18:66-72. doi: 10.1016/j.rmcr.2016.04.009. eCollection 2016.
5
Outbreak of autoimmune disease in silicosis linked to artificial stone.与人造石相关的矽肺病中自身免疫性疾病的爆发。
Occup Med (Lond). 2015 Aug;65(6):444-50. doi: 10.1093/occmed/kqv073. Epub 2015 Jun 12.
6
Notes from the field: silicosis in a countertop fabricator - Texas, 2014.实地记录：2014年，得克萨斯州一名台面制造商患矽肺病
MMWR Morb Mortal Wkly Rep. 2015 Feb 13;64(5):129-30.
7
Outbreak of silicosis in Spanish quartz conglomerate workers.西班牙石英砾岩工人矽肺暴发
Int J Occup Environ Health. 2014 Jan-Mar;20(1):26-32. doi: 10.1179/2049396713Y.0000000049.
8
Elemental analysis of occupational and environmental lung diseases by electron probe microanalyzer with wavelength dispersive spectrometer.采用带有波长色散光谱仪的电子探针微分析仪对职业性和环境性肺部疾病进行元素分析。
Respir Investig. 2014 Jan;52(1):5-13. doi: 10.1016/j.resinv.2013.05.002. Epub 2013 Jul 5.
9
Intraperitoneal injection improves the uptake of nanoparticle-labeled high-density lipoprotein to atherosclerotic plaques compared with intravenous injection: a multimodal imaging study in ApoE knockout mice.腹腔内注射比静脉内注射更能提高载脂蛋白 E 基因敲除小鼠动脉粥样硬化斑块对纳米颗粒标记的高密度脂蛋白的摄取：一项多模态成像研究。
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10
Artificial stone silicosis [corrected]: disease resurgence among artificial stone workers.人造石矽肺[已更正]：人造石工人中的疾病再现。
Chest. 2012 Aug;142(2):419-424. doi: 10.1378/chest.11-1321.

移植患者肺组织中二氧化硅含量的定量：人造石诱导的矽肺与特发性肺纤维化。

Quantitation of Silica Contents in Lung Explants of Transplanted Patients: Artificial Stone-Induced Silicosis vs. Idiopathic Pulmonary Fibrosis.

机构信息

Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel.

Environmental and Occupational Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.

出版信息

Int J Environ Res Public Health. 2021 Jul 6;18(14):7237. doi: 10.3390/ijerph18147237.

DOI:10.3390/ijerph18147237
PMID:34299685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8304914/
Abstract

Spectrophotometric techniques provide qualitative but not quantitative data on lung particles. We aimed to quantitate silica content in biopsies of lung-transplanted silicosis patients by applying X-ray fluorescence (XRF) spectrometry. Lung biopsies of 17 lung-transplanted artificial patients were quantitated for silica and other minerals particles by Niton XL3 XRF spectrometry. Occupational and clinical history data were assessed. Lung biopsies of artificial stone-induced silicosis (ASIS) patients contained significantly higher levels of silica compared to those of idiopathic pulmonary fibrosis (IPF) patients (7284.29 ± 4693.75 ppm vs. 898.88 ± 365.66 ppm, 0.0001). Silica content correlated negatively with age, body mass index, and pulmonary function test results. A 1128 ppm silica cut-off value yielded 100% sensitivity and 94% specificity for predicting ASIS (AUC = 0.94, 0.0001). In conclusion, XRF measurements in lung biopsies can differentiate between silica and mineral particles in ASIS and IPF.

摘要

分光光度技术可提供肺部颗粒的定性而非定量数据。我们旨在通过应用 X 射线荧光（XRF）光谱法来定量分析肺移植矽肺患者的活检样本中的二氧化硅含量。通过 Niton XL3 XRF 光谱仪对 17 例肺移植人工患者的活检样本进行了二氧化硅和其他矿物质颗粒的定量分析。评估了职业和临床病史数据。与特发性肺纤维化（IPF）患者相比，人工石材诱导矽肺（ASIS）患者的肺活检样本中二氧化硅含量明显更高（7284.29 ± 4693.75 ppm 比 898.88 ± 365.66 ppm，0.0001）。二氧化硅含量与年龄、体重指数和肺功能测试结果呈负相关。1128 ppm 二氧化硅截断值对预测 ASIS 具有 100%的灵敏度和 94%的特异性（AUC=0.94，0.0001）。总之，XRF 测量可区分 ASIS 和 IPF 中的二氧化硅和矿物质颗粒。