Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Environ Res Public Health. 2021 Jul 12;18(14):7424. doi: 10.3390/ijerph18147424.
Radiofrequency ablation (RFA) was first introduced for treating knee osteoarthritis (OA) in 2010 and has emerged as a minimally invasive treatment option. Three RFA techniques have been adopted for treating knee OA, including conventional, pulsed, and cooled RFA. However, the efficacy among different RFA techniques in the treatment of knee OA is still unclear. Three electronic databases were systematically searched for relevant articles, including PubMed, Embase, and Cochrane Library. A meta-analysis of articles that investigated the use of RFA techniques in the treatment of knee OA was conducted to pool the effect size in pain before and after treatment. A total of 20 eligible articles (including 605 patients) were included for our meta-analysis. After treatment, the patients had significant improvements in pain for all three RFA techniques when compared with the baseline level for the 1, 3-, and 6-month follow-ups ( < 0.00001). However, there were no significant differences in the efficacy among the three RFA techniques for all follow-up visits ( > 0.05). The three RFA techniques demonstrated a significant improvement in pain for up to 6 months after treatment. Comparing the efficacy of the three RFA techniques in the treatment of knee OA, our results showed that no significant differences in pain relief among the three RFA techniques were observed at the 1-, 3-, 6, and 12-month follow-up visits.
射频消融术（RFA）于 2010 年首次被引入膝骨关节炎（OA）的治疗，已成为一种微创治疗选择。目前有三种 RFA 技术被用于治疗膝骨关节炎，包括常规、脉冲和冷却 RFA。然而，不同 RFA 技术在膝骨关节炎治疗中的疗效仍不清楚。我们系统地检索了三个电子数据库，包括 PubMed、Embase 和 Cochrane Library，以查找有关 RFA 技术治疗膝骨关节炎的相关文章。对研究 RFA 技术治疗膝骨关节炎的文章进行荟萃分析，以汇总治疗前后疼痛的效应量。共有 20 篇符合条件的文章（包括 605 名患者）被纳入荟萃分析。与治疗前相比，所有三种 RFA 技术在治疗后 1、3 和 6 个月的随访中疼痛均有显著改善（<0.00001）。然而，在所有随访中，三种 RFA 技术的疗效之间没有显著差异（>0.05）。三种 RFA 技术在治疗后长达 6 个月内均显示出疼痛显著改善。比较三种 RFA 技术治疗膝骨关节炎的疗效，我们的结果表明，在 1、3、6 和 12 个月的随访中，三种 RFA 技术在缓解疼痛方面没有显著差异。
