Rheumatology, Fujian Medical University Provincial Clinical Medical College, Fuzhou, Fujian, China.
Rheumatology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
BMJ Open. 2021 Jul 22;11(7):e046163. doi: 10.1136/bmjopen-2020-046163.
Osteonecrosis (ON) is characterised by the destruction of the normal blood supply to the bone tissue. ON is the main cause of disability in patients with systemic lupus erythematosus (SLE). Studies have reported the existence of many risk factors for SLE complicated by ON, including the use of high-dose glucocorticoids and high disease activity. The correlation between antiphospholipid antibodies (aPLs) and ON in SLE has been controversial. We aim to conduct a systematic review of the literature related to SLE, aseptic ON and aPLs, to provide a reference for the clinical screening of high-risk patients and for early prevention.
The following six databases will be searched: MEDLINE/PubMed, Embase, Web of Science, Chinese Biomedical Literature Database, Wan-Fang Database and China National Knowledge Infrastructure. The database searches will not be restricted by date. Case-control studies, cohort studies or observational studies that compare aPLs between SLE patients with and without ON will be considered eligible. Articles published in English and Chinese will be included. Two researchers will independently perform the processes of study selection, data extraction and study quality assessment. The Newcastle-Ottawa Quality Assessment Scale will be used to assess the quality of the retrieved studies. A meta-analysis will be performed after screening the studies. Data will be analysed using ORs for dichotomous data.
Ethical approval is not required because this systematic review will use published data. The systematic review will be electronically disseminated through a peer-reviewed publication or conference presentations.
CRD42020209637.
骨坏死（ON）的特征是骨组织正常供血的破坏。ON 是系统性红斑狼疮（SLE）患者残疾的主要原因。研究报告称，SLE 并发 ON 的许多危险因素存在，包括使用大剂量糖皮质激素和高疾病活动度。抗磷脂抗体（aPLs）与 SLE 中的 ON 之间的相关性一直存在争议。我们旨在对与 SLE、无菌性 ON 和 aPLs 相关的文献进行系统回顾，为临床筛选高危患者和早期预防提供参考。
将在以下六个数据库中进行检索：MEDLINE/PubMed、Embase、Web of Science、中国生物医学文献数据库、万方数据库和中国国家知识基础设施。数据库检索不受日期限制。将纳入比较 SLE 患者有无 ON 时 aPLs 的病例对照研究、队列研究或观察性研究。将纳入英文和中文发表的文章。两名研究人员将独立进行研究选择、数据提取和研究质量评估过程。将使用纽卡斯尔-渥太华质量评估量表评估检索研究的质量。筛选研究后将进行荟萃分析。将使用二项数据的 OR 分析数据。
由于本系统评价将使用已发表的数据，因此不需要伦理批准。系统评价将通过同行评审出版物或会议演示以电子方式传播。
PROSPERO 注册号：CRD42020209637。
