Department of Rheumatology,Fujian Provincial Hospital, Fuzhou, China.
Expert Rev Clin Immunol. 2021 Aug;17(8):923-932. doi: 10.1080/1744666X.2021.1925109. Epub 2021 May 24.
: The present meta-analysis aimed to assess the relationship between antiphospholipid antibodies (aPLs) or antiphospholipid antibody syndrome (APS) and the incidence of osteonecrosis (ON) in systemic lupus erythematosus (SLE) patients.: MEDLINE/Pubmed, EMBASE, Web of science, the Chinese Biomedical Literature Database (CBM), the Wan-Fang Database, and the China National Knowledge Infrastructure (CNKI) were searched from their inception up until 26 December 2020. Studies in English were included. Case-control studies and cohort studies were included. Studies pertaining to the link between aPLs or APS and ON patients were slated for inclusion in the current analysis.: Twenty-two studies involving a total of 3054 SLE patients were included. The positivities of anticardiolipin antibody (ACL), IgG ACL, IgM ACL, LA and APS in SLE is not associated with ON. One study showed that IgG or IgM β2GP1 had no association with ON. No publication bias was detected. The quality of this evidence was low because of the high risk of bias across studies, and therefore robust inferences cannot be made.: SLE patients demonstrated a weak association between aPLs and ON. The nature of the association between aPLs and ON in SLE needs to be investigated in-depth in future research.
: 本荟萃分析旨在评估抗磷脂抗体 (aPLs) 或抗磷脂抗体综合征 (APS) 与系统性红斑狼疮 (SLE) 患者骨坏死 (ON) 发生率之间的关系。: 检索了 MEDLINE/Pubmed、EMBASE、Web of science、中国生物医学文献数据库 (CBM)、万方数据库和中国知网 (CNKI) 从建库到 2020 年 12 月 26 日的数据。纳入英文研究。纳入病例对照研究和队列研究。与 aPLs 或 APS 与 ON 患者之间的联系相关的研究被纳入本分析。: 共纳入 22 项研究，总计 3054 例 SLE 患者。抗心磷脂抗体 (ACL)、IgG ACL、IgM ACL、LA 和 APS 的阳性与 ON 无关。一项研究表明 IgG 或 IgM β2GP1 与 ON 无关。未检测到发表偏倚。由于研究间存在高偏倚风险，因此证据质量较低，因此无法得出可靠的推论。: SLE 患者的 aPLs 与 ON 之间存在弱相关性。需要在未来的研究中深入研究 SLE 中 aPLs 与 ON 之间的关联性质。
