Chaliha Devahuti, Vaccarezza Mauro, Lam Virginie, Takechi Ryusuke, Mamo John C
Curtin Health Innovation Research Institute, Curtin University, Bentley, WA,, Australia.
School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, WA,, Australia.
Eur J Clin Nutr. 2022 Feb;76(2):317-319. doi: 10.1038/s41430-021-00962-x. Epub 2021 Jul 23.
A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g L-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of L-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of L-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients.
一名74岁女性，其发作性紧张性头痛的治疗效果欠佳，接受了每日剂量为1.5克L-精氨酸和1.2克陈年大蒜提取物（AGE）的治疗。干预的目的是促进脑实质血管的血管舒张。在开始治疗的6周内，她自我报告的症状明显改善，并在开始治疗后的2年里持续保持。我们认为，L-精氨酸和AGE对该患者的假定有益作用是由于L-精氨酸和陈年大蒜提取物已明确的全身血管舒张作用。基于偏头痛是由脑微血管收缩引发的这一假设，我们建议进行一项双盲随机对照试验，以在偏头痛患者中对这一假设进行临床检验。
