Suppr超能文献

文拉法辛可能通过下调 TNF-α、IL-6、IL-1β 和 COX-2 发挥抗关节炎活性。

Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2.

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia.

College of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan.

出版信息

Inflammopharmacology. 2021 Oct;29(5):1413-1425. doi: 10.1007/s10787-021-00849-0. Epub 2021 Jul 24.

Abstract

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used to treat depression. Previous studies demonstrated its anti-nociceptive and anti-inflammatory activities through the suppression of pro-inflammatory cytokines. Present research aimed to explore its anti-arthritic potential. Different in-vitro assays including egg albumin, bovine serum albumin denaturation and human red blood cell (RBC) membrane stabilization assays along with in-vivo models of formaldehyde and complete Freund's adjuvant-induced arthritis were used to study its anti-arthritic effect. Venlafaxine inhibited egg albumin and bovine serum albumin denaturation and preserve the integrity of red blood cells membrane in concentration-dependent manner. In formaldehyde-induced arthritis venlafaxine significantly (p < 0.001) reduced the paw edema on treatment for 10 days. Chronic administration of venlafaxine for 28 days in Freund's adjuvant-induced arthritis model decreased the paw volume (p < 0.001), arthritic index (p < 0.01), flexion pain score (p < 0.05), mobility score (p < 0.05), and improved the stance score (p < 0.05). Venlafaxine also significantly declined the rheumatoid factor (p < 0.01) and C-reactive protein (p < 0.05) levels and increased the RBC count (p < 0.01) and Hb value (p < 0.001). Upon PCR analysis venlafaxine remarkably turndown the mRNA expression of TNF-α, IL-6, IL-1β, and COX-2. Taken together it is inferred from current findings that venlafaxine possesses the significant anti-arthritic activity and could be a potential therapeutic option for the treatment of rheumatoid arthritis.

摘要

文拉法辛是一种 5-羟色胺和去甲肾上腺素再摄取抑制剂,用于治疗抑郁症。先前的研究表明,它通过抑制促炎细胞因子具有抗伤害感受和抗炎活性。目前的研究旨在探索其抗关节炎的潜力。使用不同的体外试验,包括卵白蛋白、牛血清白蛋白变性和人红细胞(RBC)膜稳定性试验,以及甲醛和完全弗氏佐剂诱导的关节炎的体内模型,研究其抗关节炎作用。文拉法辛以浓度依赖的方式抑制卵白蛋白和牛血清白蛋白变性并保持红细胞膜的完整性。在甲醛诱导的关节炎中,文拉法辛在治疗 10 天内显著(p<0.001)减轻爪肿胀。在弗氏佐剂诱导的关节炎模型中,文拉法辛连续给药 28 天,降低爪体积(p<0.001)、关节炎指数(p<0.01)、弯曲疼痛评分(p<0.05)、运动评分(p<0.05)和改善站立评分(p<0.05)。文拉法辛还显著降低类风湿因子(p<0.01)和 C 反应蛋白(p<0.05)水平,并增加红细胞计数(p<0.01)和 Hb 值(p<0.001)。通过 PCR 分析,文拉法辛显著下调 TNF-α、IL-6、IL-1β 和 COX-2 的 mRNA 表达。综上所述,从目前的研究结果推断,文拉法辛具有显著的抗关节炎活性,可能是治疗类风湿关节炎的一种潜在治疗选择。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验