Department of International Health, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain; World Community for Prevention of Diabetes (WCPD) Foundation, Madrid, Spain.
Department of Public Health, Universidad del Norte, Barranquilla, Colombia.
Diabetes Res Clin Pract. 2021 Aug;178:108976. doi: 10.1016/j.diabres.2021.108976. Epub 2021 Jul 22.
/hypothesis. To determine the best cut-off threshold value of the Finnish Diabetes Risk Score (FINDRISC) for the detection of diabetes and non-diabetic hyperglycaemia in people 35 years or older at primary health care settings in Europe.
Cross-sectional study in 11,444 adults from primary health care centres using community and opportunistic screening approaches. All participants completed the FINDRISC questionnaire and underwent a 2-hour oral glucose tolerance test (OGTT). The FINDRISC performance was assessed by the area under the curve (AUC) using receiver operating characteristics (ROC) analysis. The sensitivity, specificity, Youdeńs index, positive and negative prediction values for different FINDRISC cut-offs were calculated.
The optimal FINDRISC value for detecting both diabetes or glucose impairment in the community - screened sample was 14 point with the associated AUC 0.75,5 (95 %CI 0.73,7-0.77,3). The optimal score in the opportunistic screening sample was 16 with the associated AUC only 0.60,4 (95% CI 0.56, 4-0.64, 4).
CONCLUSIONS/INTERPRETATION: The FINDRISC is a non-invasive tool useful for detecting people with unknown diabetes and glucose impairment in people visiting primary health centres in Europe.
/假说。确定芬兰糖尿病风险评分(FINDRISC)在欧洲初级保健机构中用于检测 35 岁及以上人群糖尿病和非糖尿病高血糖的最佳截断值。
在使用社区和机会性筛查方法的 11444 名成年人中进行横断面研究。所有参与者完成 FINDRISC 问卷并接受 2 小时口服葡萄糖耐量试验(OGTT)。使用接收者操作特征(ROC)分析评估 FINDRISC 的曲线下面积(AUC)。计算不同 FINDRISC 截断值的敏感性、特异性、Youden 指数、阳性和阴性预测值。
在社区筛查样本中,用于检测糖尿病或葡萄糖损害的最佳 FINDRISC 值为 14 分,相关 AUC 为 0.755(95%CI 0.73,7-0.77,3)。在机会性筛查样本中,最佳评分是 16,相关 AUC 仅为 0.604(95%CI 0.56,4-0.64,4)。
结论/解释:FINDRISC 是一种非侵入性工具,可用于检测在欧洲初级保健中心就诊的人群中未知的糖尿病和葡萄糖损害。