Unit of Dermatology and Sexually Transmitted Diseases, University of Palermo, Palermo, Italy;
Unit of Dermatology and Sexually Transmitted Diseases, University of Palermo, Palermo, Italy.
Skinmed. 2021 Jun 1;19(3):189-196. eCollection 2021.
The current medical treatments of androgenetic alopecia (AGA) have hardly achieved a satisfying clinical improvement. Biologic regenerative therapies, such as platelet-rich plasma (PRP) injections in the scalp, have been proposed recently. This multidisciplinary prospective study aims to explore the efficacy and safety of autologous PRP injections into the scalp of patients with AGA. Fifty-four patients with AGA (35 men and 19 women) were enrolled. Non-activated autologous PRP was injected into the androgen-related areas of the scalp. The study protocol consisted of three sessions of injections at 3-month interval. The effects were assessed by means of noninvasive methods. Safety profile, patient satisfaction, and Dermatology Life Quality Index were assessed. Increase in hair thickness was observed 1 month after the first PRP injection, and hair loss reduction was found after 3 months. In most patients, the improvement was progressively evident until the 12th month. Hair growth/production showed differences between women and men. The safety profile was satisfactory. This study confirms that PRP injections are effective in reducing thinning of the scalp hair and suggests more efficacy in women.
目前雄激素性脱发（AGA）的医学治疗方法几乎没有取得令人满意的临床改善。最近提出了生物再生疗法，例如头皮富血小板血浆（PRP）注射。本多学科前瞻性研究旨在探讨自体 PRP 注射治疗 AGA 患者头皮的疗效和安全性。共纳入 54 例 AGA 患者（男性 35 例，女性 19 例）。将非激活的自体 PRP 注入头皮的雄激素相关区域。研究方案包括每 3 个月进行 3 次注射。采用非侵入性方法评估效果。评估安全性、患者满意度和皮肤病生活质量指数。首次 PRP 注射后 1 个月观察到头发厚度增加，3 个月后发现脱发减少。在大多数患者中，改善情况直到第 12 个月才逐渐明显。头发的生长/产生在女性和男性之间存在差异。安全性良好。本研究证实 PRP 注射可有效减少头皮头发稀疏，并提示女性更有效。
