Bayat Mousa, Yazdanpanah Mohammad Javad, Hamidi Alamdari Daryoush, Banihashemi Mahnaz, Salehi Maryam
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cosmet Dermatol. 2019 Dec;18(6):1624-1628. doi: 10.1111/jocd.12907. Epub 2019 Mar 20.
Androgenetic alopecia is the most common type of hair loss in men, which is manifested by a progressive terminal hair loss in specific areas of scalp. Platelet-rich plasma (PRP) is among treatment options for androgenetic alopecia. PRP is a human platelet concentrate in a small volume of plasma containing certain cytokines.
The aim of this study was to evaluate the efficacy and safety of autologous PRP in treatment of male androgenetic alopecia.
This was a clinical trial in 19 patients with grade III vertex to grade V androgenetic alopecia referring to the Clinic of Ghaem Hospital between March 2015 and March 2016. All obtained liquid PRP (5 cc) was injected at around 125 points (equals to 125 cm ) into the scalp, and operation was repeated in three sessions at 0, 4, and 8 weeks. We took macroscopic and dermoscopic pictures of each patient in 0, 4, and 8 weeks and 3 months after the last injection session. A dermatologist evaluated the treatment response using dermoscopy photos.
Our results showed that the trend of hair thickness and number variations during study period was significant (P < 0.001). However, there was no significant change in the hair thickness from the second injection forward. Our findings indicate the number of hair follicles during follow-up in pairwise comparison was significantly more than baseline.
Findings of our study were in line with other studies in this field and showed that the use of PRP as a new and safe treatment can be effective in androgenetic alopecia.
雄激素性脱发是男性最常见的脱发类型，表现为头皮特定区域的终毛进行性脱落。富血小板血浆（PRP）是雄激素性脱发的治疗选择之一。PRP是一种浓缩在少量含有某些细胞因子的血浆中的人体血小板。
本研究旨在评估自体PRP治疗男性雄激素性脱发的疗效和安全性。
这是一项针对2015年3月至2016年3月期间转诊至加姆医院诊所的19例III级至V级头顶雄激素性脱发患者的临床试验。将所有获得的液体PRP（5毫升）在约125个点（相当于125平方厘米）注射到头皮中，并在0、4和8周分三个疗程重复操作。我们在每次注射疗程后的0、4、8周和3个月拍摄了每位患者的宏观和皮肤镜照片。一名皮肤科医生使用皮肤镜照片评估治疗反应。
我们的结果表明，研究期间头发厚度和数量变化的趋势具有显著性（P<0.001）。然而，从第二次注射后头发厚度没有显著变化。我们的研究结果表明，在两两比较中，随访期间毛囊数量明显多于基线。
我们的研究结果与该领域的其他研究一致，表明使用PRP作为一种新的安全治疗方法对雄激素性脱发可能有效。
