11例CD20阳性结外NK/T细胞淋巴瘤临床分析
[Clinical analysis of 11 cases of CD20 positive extranodal NK/T cell lymphoma].
作者信息
Yang Shuangshuang, Ba Yunpeng, Jiang Guozhong
机构信息
Department of Rhinology，First Affiliated Hospital，Zhengzhou University，Zhengzhou，450052，China.
Department of Pathology，First Affiliated Hospital，Zhengzhou University.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 May;35(5):436-440. doi: 10.13201/j.issn.2096-7993.2021.05.012.
Abstract
To explore the clinical features and prognosis of CD20-positive extranodal NK/T cell lymphoma. To analyze the clinical characteristics and prognosis of 11 ENKTL patients admitted to this hospital. Among the 11 patients, 6 cases with elevated LDH, 6 cases of anemia, and 8 cases with Ki-67≥50%. Two cases survived; 1 case lost contact; 8 cases died, and the average survival time of 8 cases was 22.5 months. The diagnosis of CD20 positive ENKTL is difficult, which requires a combination pathomorphology, immunohistochemistry, EBER and gene rearrangement detection and improve the understanding of the disease.Early diagnosis and active treatment is important.
摘要
探讨CD20阳性结外NK/T细胞淋巴瘤的临床特征及预后。分析本院收治的11例鼻型结外NK/T细胞淋巴瘤（ENKTL）患者的临床特点及预后。11例患者中，乳酸脱氢酶（LDH）升高6例，贫血6例，Ki-67≥50% 8例。2例存活；1例失访；8例死亡，8例平均生存时间为22.5个月。CD20阳性ENKTL的诊断困难，需结合病理形态学、免疫组化、EBER及基因重排检测，提高对该病的认识。早期诊断及积极治疗很重要。
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