[白细胞介素-8在慢性鼻-鼻窦炎中的表达及作用]
[The expression and role of interleukin-8 in chronic rhinosinusitis].
作者信息
Wang Yaojie, Li Chunhua, Liu Hongbing
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug;35(8):765-768. doi: 10.13201/j.issn.2096-7993.2021.08.020.
Abstract
Interleukin-8（IL-8） is an inflammatory factor secreted by multiple cells. It has a variety of biological effects such as trending inflammatory cells and promoting angiogenesis in the body. Currently, it is found to play an important role in promoting airway inflammation. Chronic rhinosinusitis is a chronic inflammatory disease of the nasal cavity and sinus mucosa. Under the stimulation of a variety of factors, the secretion of IL-8 in the nasal mucosa and nasal polyps of CRS patients could increase. Therefore, it can cause inflammation and mucosal damage by trending chemotaxis neutrophils and eosinophils.
摘要
白细胞介素-8（IL-8）是一种由多种细胞分泌的炎症因子。它具有多种生物学效应，如趋化炎症细胞和促进体内血管生成。目前发现它在促进气道炎症中起重要作用。慢性鼻窦炎是鼻腔和鼻窦黏膜的慢性炎症性疾病。在多种因素刺激下，慢性鼻窦炎患者鼻黏膜和鼻息肉中IL-8的分泌会增加。因此，它可通过趋化中性粒细胞和嗜酸性粒细胞导致炎症和黏膜损伤。
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