Brunet Aina, Milara Javier, Frías Soledad, Cortijo Julio, Armengot Miguel
Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Bellvitge, 08907 Barcelona, Spain.
Institut d'Investigació Biomèdica (IDIBELL), 08908 Barcelona, Spain.
J Clin Med. 2023 Feb 9;12(4):1391. doi: 10.3390/jcm12041391.
(1) Background: Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients' QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance ( = 0.04) and the endoscopic polyp score ( = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia ( = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP.
(1) 背景：影响伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）患者生活质量（QoL）的因素尚不清楚。我们旨在使用鼻鼻窦结局测试-22（SNOT-22）来确定患者生活质量的预测因素；(2) 方法：对在我们机构被诊断为CRSwNP的患者的数据进行前瞻性和回顾性分析。所有患者均接受鼻息肉活检并完成SNOT-22问卷。收集人口统计学和分子数据以及SNOT-22评分。根据是否存在哮喘、非甾体类药物（NSAID）不耐受和糖皮质激素抵抗将患者分为六个亚组；(3) 结果：SNOT-22平均评分为39分。考虑临床参数，SNOT-22值与NSAID不耐受（P = 0.04）和内镜下息肉评分（P = 0.04）显著相关。高SNOT-22值也与高组织嗜酸性粒细胞增多（P = 0.01）和高白细胞介素-8表达相关；(4) 结论：嗜酸性粒细胞增多、白细胞介素-8表达和NSAID不耐受可作为CRSwNP患者生活质量较差的预测指标。
