Department of Chemistry, Indian Academy Degree College-Autonomous, Bangalore, India.
P.G. Department of Chemistry, Vijaya College, Bangalore, India.
Nat Prod Res. 2022 Jun;36(12):3054-3068. doi: 10.1080/14786419.2021.1955361. Epub 2021 Jul 26.
Naturally occurring bioactive molecules are known for their diverse biological applications such as antimicrobial, anticancer, anti-inflammatory, and analgesic activities. Also, some of the natural products act as medicinal drugs. Further, bioactive cell-permeable molecule embelin has been reported for its diverse biological activities such as antimalarial, anticancer, and anti-inflammatory in the literature. With the continuation of our research work on biologically active molecules, based on structural activity relationship and docking studies of embelin and its derivatives, we have reported target-specific anticancer and antimalarial activities of embelin and its analogs. Also, it has been reported in many recent research articles that embelin and its derivatives are known to possess medicinal properties. This review mainly highlights recent reports on broad-spectrum biological activities of the embelin and its analogs to date.
天然生物活性分子以其多样的生物应用而闻名,如抗菌、抗癌、抗炎和镇痛活性。此外,一些天然产物还具有药用价值。此外,生物活性细胞通透分子杨梅素在文献中因其多种生物活性而被报道,如抗疟、抗癌和抗炎。随着我们对生物活性分子的研究工作的继续,基于杨梅素及其衍生物的构效关系和对接研究,我们已经报道了杨梅素及其类似物的针对特定靶标的抗癌和抗疟活性。此外,许多最近的研究文章也报道了杨梅素及其衍生物具有药用特性。本篇综述主要强调了迄今为止杨梅素及其类似物的广谱生物活性的最新报道。