Ali Asad, Emad Nasr A, Sultana Niha, Ali Hamad, Jahan Samreen, Aqil Mohd, Mujeeb Mohd, Sultana Yasmin
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Department of Phytochemistry and Pharmacognosy, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Iran J Basic Med Sci. 2024;27(10):1228-1242. doi: 10.22038/ijbms.2024.77888.16850.
Natural herbs have garnered significant research recently as their components target multiple disease signaling pathways, making them highly potential for various disease prevention and treatment. Embelin, a naturally occurring benzoquinone isolated from , has shown promising biological activities such as antitumor, antidiabetic, anti-oxidant, and antimicrobial. Various mechanisms have been reported, including monitoring genes that synchronize the cell cycle, up-regulating multiple anti-oxidant enzymes, suppressing genes that prevent cell death, influencing transcription factors, and preventing inflammatory biomarkers. However, the hydrophobic nature of embelin leads to poor absorption and limits its therapeutic potential. This review highlights a wide range of nanocarriers used as delivery systems for embelin, including polymeric nanoparticles, liposomes, nanostructured lipid carriers, micelles, nanoemulsion, and metallic nanoparticles. These embelin nanomedicine formulations have been developed in preclinical studies as a possible treatment for many disorders and characterized using various , and models.
天然草药最近获得了大量研究，因为其成分靶向多种疾病信号通路，使其在各种疾病的预防和治疗方面具有很高的潜力。从[具体来源未提及]中分离出的天然存在的苯醌——紫铆因，已显示出有前景的生物活性，如抗肿瘤、抗糖尿病、抗氧化和抗菌。已报道了多种机制，包括监测同步细胞周期的基因、上调多种抗氧化酶、抑制阻止细胞死亡的基因、影响转录因子以及阻止炎症生物标志物。然而，紫铆因的疏水性导致其吸收不佳，并限制了其治疗潜力。本综述重点介绍了用作紫铆因递送系统的多种纳米载体，包括聚合物纳米颗粒、脂质体、纳米结构脂质载体、胶束、纳米乳液和金属纳米颗粒。这些紫铆因纳米药物制剂已在临床前研究中开发，作为许多疾病的可能治疗方法，并使用各种[具体未提及的方法]和[具体未提及的模型]进行了表征。
