来自[具体来源未提及]的菲及其胰腺脂肪酶抑制活性。

Phenanthrenes from and their pancreatic lipase inhibitory activity.

作者信息

Pann Phyu Myat, Kongkatitham Virunh, Mekboonsonglarp Wanwimon, Likhitwitayawuid Kittisak, Sritularak Boonchoo

机构信息

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Scientific and Technological Research Equipment Centre, Chulalongkorn University, Bangkok 10330, Thailand.

出版信息

J Asian Nat Prod Res. 2022 Jul;24(7):697-702. doi: 10.1080/10286020.2021.1956478. Epub 2021 Jul 24.

DOI:10.1080/10286020.2021.1956478

PMID:34304660

Abstract

From the whole plant of , a new phenanthrene namely 2,5,7-trihydroxy-4-methoxyphenanthrene () was isolated, together with seven known compounds including moscatin (), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (), moscatilin (), aloifol I (), 4,4',8,8'-tetramethoxy[1,1'-biphenanthrene]-2,2',7,7'-tetrol (), 2,2',7,7'-tetrahydroxy-4,4'-dimethoxy-1,1'-biphenanthrene () and bleformin G (). The structure of the new compound was elucidated by analysis of its spectroscopic data. Moscatin () and 2,5-dihydroxy-4,9-dimethoxyphenanthrene () showed appreciable pancreatic lipase inhibitory effects when compared with the positive control orlistat.

摘要

从[植物名称]的全株中分离出一种新的菲类化合物，即2,5,7-三羟基-4-甲氧基菲（[化合物名称]），以及七种已知化合物，包括莫斯卡亭（[化合物名称]）、2,5-二羟基-4,9-二甲氧基菲（[化合物名称]）、莫斯卡替林（[化合物名称]）、芦荟酚I（[化合物名称]）、4,4',8,8'-四甲氧基[1,1'-联菲]-2,2',7,7'-四醇（[化合物名称]）、2,2',7,7'-四羟基-4,4'-二甲氧基-1,1'-联菲（[化合物名称]）和博来霉素G（[化合物名称]）。通过对其光谱数据的分析阐明了新化合物的结构。与阳性对照奥利司他相比，莫斯卡亭（[化合物名称]）和2,5-二羟基-4,9-二甲氧基菲（[化合物名称]）显示出明显的胰脂肪酶抑制作用。