一种来自睑叶石斛的新菲二聚体。
A new phenanthrene dimer from Dendrobium palpebrae.
作者信息
Kyokong Napat, Muangnoi Chawanphat, Thaweesest Wuttinont, Kongkatitham Virunh, Likhitwitayawuid Kittisak, Rojsitthisak Pornchai, Sritularak Boonchoo
机构信息
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok 10330 , Thailand.
b Pharmaceutical Chemistry and Natural Products Program, Faculty of Pharmaceutical Sciences , Chulalongkorn University , Bangkok 10330 , Thailand.
出版信息
J Asian Nat Prod Res. 2019 Apr;21(4):391-397. doi: 10.1080/10286020.2018.1429416. Epub 2018 Jan 25.
A new phenanthrene dimer, namely dendropalpebrone (1), was isolated from the whole plant of Dendrobium palpebre, along with nine known compounds (2-10). All of the isolates were evaluated for their hydroxyl radical scavenging effects using a deoxyribose assay. Dendroflorin (10) showed an appreciable activity, and therefore was selected for further studied in RAW264.7 cells. Compound 10 significantly decreased ROS in HO-stimulated RAW264.7 cells in a dose-dependent manner, and improved activity of SOD, GPx, and CAT enzymes.
从睑叶石斛全草中分离出一种新的菲二聚体，即睑叶石斛酮（1），以及9种已知化合物（2 - 10）。使用脱氧核糖分析对所有分离物的羟自由基清除作用进行了评估。毛兰素（10）表现出明显的活性，因此被选用于在RAW264.7细胞中进行进一步研究。化合物10以剂量依赖性方式显著降低HO刺激的RAW264.7细胞中的活性氧，并提高超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶的活性。
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