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大麻素调节早期嗅觉和视觉神经回路中的感觉处理。

Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits.

机构信息

Department of Anatomy, Howard University College of Medicine, Washington, DC, United States.

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States.

出版信息

Front Neural Circuits. 2021 Jul 7;15:662349. doi: 10.3389/fncir.2021.662349. eCollection 2021.

DOI:10.3389/fncir.2021.662349
PMID:34305536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8294086/
Abstract

Our sensory systems such as the olfactory and visual systems are the target of neuromodulatory regulation. This neuromodulation starts at the level of sensory receptors and extends into cortical processing. A relatively new group of neuromodulators includes cannabinoids. These form a group of chemical substances that are found in the cannabis plant. Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main cannabinoids. THC acts in the brain and nervous system like the chemical substances that our body produces, the endogenous cannabinoids or endocannabinoids, also nicknamed the brain's own cannabis. While the function of the endocannabinoid system is understood fairly well in limbic structures such as the hippocampus and the amygdala, this signaling system is less well understood in the olfactory pathway and the visual system. Here, we describe and compare endocannabinoids as signaling molecules in the early processing centers of the olfactory and visual system, the olfactory bulb, and the retina, and the relevance of the endocannabinoid system for synaptic plasticity.

摘要

我们的感觉系统，如嗅觉和视觉系统，是神经调质调节的目标。这种神经调质调节始于感觉受体水平，并延伸到皮质处理。相对较新的一类神经调质包括大麻素。这些化学物质存在于大麻植物中。Δ9-四氢大麻酚（THC）和大麻二酚（CBD）是主要的大麻素。THC 在大脑和神经系统中的作用类似于我们身体产生的化学物质，即内源性大麻素或内源性大麻素，也被称为大脑自身的大麻。虽然内源性大麻素系统在海马体和杏仁核等边缘结构中的功能相当清楚，但这个信号系统在嗅觉通路和视觉系统中的作用还不太清楚。在这里，我们描述并比较了内源性大麻素作为嗅觉和视觉系统早期处理中心——嗅球和视网膜中的信号分子，以及内源性大麻素系统对突触可塑性的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/cf31509e3f80/fncir-15-662349-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/1d28a6d5c453/fncir-15-662349-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/36ffdfc5de4d/fncir-15-662349-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/b36bd96dc5ae/fncir-15-662349-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/b57c444e5bc8/fncir-15-662349-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/c24dc0108eda/fncir-15-662349-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/6cfe367cd25b/fncir-15-662349-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/c9f5759247f8/fncir-15-662349-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/3e3463b0099a/fncir-15-662349-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/cf31509e3f80/fncir-15-662349-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/1d28a6d5c453/fncir-15-662349-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/36ffdfc5de4d/fncir-15-662349-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/b36bd96dc5ae/fncir-15-662349-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/b57c444e5bc8/fncir-15-662349-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/c24dc0108eda/fncir-15-662349-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/6cfe367cd25b/fncir-15-662349-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/c9f5759247f8/fncir-15-662349-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/3e3463b0099a/fncir-15-662349-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9060/8294086/cf31509e3f80/fncir-15-662349-g0009.jpg

相似文献

[1]
Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits.

Front Neural Circuits. 2021

[2]
Endocannabinoid-mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing.

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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引用本文的文献

[1]
Cannabinoid regulation of sex-dependent murine odorant-stimulated salivation.

Sci Rep. 2024-11-4

[2]
Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina.

iScience. 2024-5-7

[3]
Endogenous cannabinoids in the piriform cortex tune olfactory perception.

Nat Commun. 2024-2-9

[4]
The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans.

Curr Biol. 2023-5-8

[5]
Chemical Constituents of Essential Oils Used in Olfactory Training: Focus on COVID-19 Induced Olfactory Dysfunction.

Front Pharmacol. 2022-6-2

[6]
Illicit Drug Use and Smell and Taste Dysfunction: A National Health and Nutrition Examination Survey 2013-2014.

Healthcare (Basel). 2022-5-13

[7]
Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling.

Ageing Res Rev. 2022-1

本文引用的文献

[1]
Endocannabinoid-mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing.

Eur J Neurosci. 2022-2

[2]
Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids.

Front Cell Neurosci. 2021-2-9

[3]
Cannabinoids affect the mouse visual acuity via the cannabinoid receptor type 2.

Sci Rep. 2020-9-25

[4]
Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats.

Behav Pharmacol. 2022-4-1

[5]
Potential for endocannabinoid system modulation in ocular pain and inflammation: filling the gaps in current pharmacological options.

Neuronal Signal. 2018-11-2

[6]
Structure and flexibility in cortical representations of odour space.

Nature. 2020-7-1

[7]
Cannabinoid Control of Olfactory Processes: The Matters.

Genes (Basel). 2020-4-16

[8]
Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina.

Invest Ophthalmol Vis Sci. 2020-3-9

[9]
Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

BMC Genomics. 2020-3-3

[10]
Cell types and cell circuits in human and non-human primate retina.

Prog Retin Eye Res. 2020-2-5

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