Javaid Farah, Mehmood Malik Hassan, Shaukat Bushra
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University of Faisalabad, Faisalabad, Pakistan.
Front Pharmacol. 2021 Jul 9;12:670433. doi: 10.3389/fphar.2021.670433. eCollection 2021.
Hance () has been used widely in traditional Chinese and Ayurvedic medicines. Its folkloric uses include relieving stomach ache, treating cold, improving the circulatory system, and reducing swelling. Its effectiveness and mechanism of antihypertension in obesity-induced hypertensive rats have not been studied yet as per our knowledge. This study has been designed to provide evidence of underlying mechanisms to the medicinal use of as a cardiotonic using an obesity-induced hypertension model in rats. Chronic administration of caused a marked reduction in the body weight gain and Lee index of rats compared to the obesogenic diet-fed rats. Its administration also caused attenuation in blood pressure (systolic, diastolic, and mean), serum total cholesterol, triglyceride, and leptin, while an increase in serum HDL and adiponectin levels was noticed. The catalase and superoxide dismutase enzymatic activities were found to be remarkable in the serum of -treated animal groups. showed mild to moderate diuretic, hepatoprotective, and reno-protective effects. treated group showed less mRNA expression of 3-hydroxy-3-methylglutaryl-CoA reductase while the mRNA expression of peroxisome proliferator-activated receptor and mRNA expression of cholesterol 7 alpha-hydroxylase were raised in comparison to the hypertensive group of rats evaluated by quantitative real-time polymerase chain reaction. These findings show that possesses antihypertensive and diuretic activities, thus providing a rationale to the medicinal use of in cardiovascular ailments.
汉防己（Hance）已广泛应用于传统中药和阿育吠陀医学。其民间用途包括缓解胃痛、治疗感冒、改善循环系统和减轻肿胀。据我们所知，其在肥胖诱导的高血压大鼠中的降压效果及机制尚未得到研究。本研究旨在利用大鼠肥胖诱导高血压模型，为汉防己作为强心剂药用的潜在机制提供证据。与喂食致肥胖饮食的大鼠相比，长期给予汉防己导致大鼠体重增加和李氏指数显著降低。其给药还导致血压（收缩压、舒张压和平均压）、血清总胆固醇、甘油三酯和瘦素水平降低，同时血清高密度脂蛋白和脂联素水平升高。在接受汉防己治疗的动物组血清中发现过氧化氢酶和超氧化物歧化酶的酶活性显著。汉防己表现出轻度至中度的利尿、肝保护和肾保护作用。通过定量实时聚合酶链反应评估，与高血压大鼠组相比，汉防己治疗组3-羟基-3-甲基戊二酰辅酶A还原酶的mRNA表达降低，而过氧化物酶体增殖物激活受体的mRNA表达和胆固醇7α-羟化酶的mRNA表达升高。这些发现表明汉防己具有降压和利尿活性，从而为其在心血管疾病中的药用提供了理论依据。
