Lei Xia, Wang Jiapeng, Zuo Kun, Xia Tianli, Zhang Jinfeng, Xu Xiangyue, Liu Qing, Li Xiaoliang
Jiangsu MC Clinical Innovation Center of Degenerative Bone and Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China.
Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education and International Joint Research Center of Human-Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province and Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs and Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University, Haikou, Hainan, China.
Front Pharmacol. 2024 Aug 16;15:1414635. doi: 10.3389/fphar.2024.1414635. eCollection 2024.
The dried root and rhizome of Hance () have been widely used in traditional Chinese medicine for thousands of years to alleviate pain, promote digestion, warm the stomach, and disperse cold. This review aims to comprehensively and in-depth summarize the most recent research on the traditional uses, phytochemistry, pharmacokinetics, and pharmacology of . By searching various databases including Web of Science, PubMed, Google Scholar, Elsevier, Springer, ScienceDirect, and China National Knowledge Infrastructure (CNKI) for literature on " Hance," as well as relevant textbooks and digital documents, an overall and critical review of the subject was conducted. The traditional uses of were summarized, and 337 compounds from were summarized, including flavonoids, diarylheptanoids, volatile oils, and other compounds. Studies have found that the crude extract of and its compounds has a wide range of biological activities, such as improving gastrointestinal function, anti-inflammatory properties, anti-tumor activity, antibacterial properties, memory enhancement, and analgesic effects. Modern pharmacological studies have provided strong evidence and explanations for the traditional medicinal uses of , which brings a broad prospect for its medicinal use. However, more research is needed to explore the structure-activity relationship and potential mechanisms of action of its bioactive chemicals. Furthermore, it is essential to conduct more clinical trials in order to accelerate research and development of the drug.
华细辛（Hance）的干燥根及根茎在传统中药中已被广泛使用了数千年，用于缓解疼痛、促进消化、温暖胃部及驱散寒邪。本综述旨在全面且深入地总结关于华细辛传统用途、植物化学、药代动力学及药理学的最新研究。通过在包括科学网、PubMed、谷歌学术、爱思唯尔、施普林格、ScienceDirect及中国知网（CNKI）等各种数据库中检索关于“华细辛”的文献，以及相关教科书和数字文档，对该主题进行了全面且批判性的综述。总结了华细辛的传统用途，并汇总了从华细辛中分离出的337种化合物，包括黄酮类、二芳基庚烷类、挥发油及其他化合物。研究发现，华细辛的粗提取物及其化合物具有广泛的生物活性，如改善胃肠功能、抗炎特性、抗肿瘤活性、抗菌特性、增强记忆及镇痛作用。现代药理学研究为华细辛的传统药用提供了有力证据及解释，为其药用带来了广阔前景。然而，需要更多研究来探索其生物活性化学成分的构效关系及潜在作用机制。此外，开展更多临床试验以加速该药物的研发至关重要。
