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中药 的化学与药理研究进展。

The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine, .

机构信息

Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.

Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China.

出版信息

Molecules. 2022 Sep 2;27(17):5678. doi: 10.3390/molecules27175678.

Abstract

Since the outbreak of the COVID-19 pandemic, traditional Chinese medicine has played an important role in the treatment process. Furthermore, the discovery of artemisinin in has reduced the incidence of malaria all over the world. Therefore, it is becoming urgent and important to establish a novel method of conducting systematic research on Chinese herbal medicine, improving the medicinal utilization value of traditional Chinese medicine and bringing great benefits to human health all over the world. , a kind of Chinese herbal medicine which has been recorded in the "" (2020 edition), refers to the dry, ripe fruits of L. Recently, some studies have shown that exhibits some special pharmacological activities; for example, it has diuretic, anti-diabetes, antioxidant and anti-tumor properties, and it alleviates hair loss. Furthermore, according to the reports, the active ingredients separated and identified from contain some very novel compounds such as nortangeretin-8-O-β-d-glucuronopyranoside and 1-O-(6-deoxy-6-sulfo)-glucopyranosyl-2-O-linolenoyl-3-O-palmitoyl glyceride, which could be screened as important candidate compounds for diabetes- or tumor-treatment drugs, respectively. Therefore, in this research, we take as an example and systematically summarize the chemical constituents and pharmacological activity research progress of it. This review will be helpful in promoting the development and application of and will also provide an example for other investigations of traditional Chinese medicine.

摘要

自 COVID-19 大流行爆发以来,中药在治疗过程中发挥了重要作用。此外,青蒿素的发现 降低了全世界疟疾的发病率。因此,迫切需要建立一种新的方法来对中草药进行系统研究,提高中药的药用价值,为全世界人类健康带来巨大益处。 ,一种已被《中国药典》(2020 年版)收录的中草药,指的是 L. 的干燥、成熟果实。最近的一些研究表明, 具有一些特殊的药理活性;例如,它具有利尿、抗糖尿病、抗氧化和抗肿瘤作用,并能缓解脱发。此外,据报道,从 中分离和鉴定的活性成分含有一些非常新颖的化合物,如橙皮素-8-O-β-d-葡萄糖醛酸苷和 1-O-(6-去氧-6-磺酸基)-葡萄糖基-2-O-亚油酰基-3-O-棕榈酰甘油,它们可以分别作为治疗糖尿病或肿瘤药物的重要候选化合物进行筛选。因此,在本研究中,我们以 为例,系统总结了其化学成分和药理活性研究进展。本综述将有助于促进 的开发和应用,并为其他中药研究提供范例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f11/9458057/c5ab80e2bc1e/molecules-27-05678-g001.jpg

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