自噬在肝纤维化中的作用。
The role of autophagy in hepatic fibrosis.
作者信息
Sun Mei, Tan Li, Hu Min
机构信息
Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):5747-5757. eCollection 2021.
Abstract
Hepatic fibrosis is a chronic liver injury process, and its continuous development can lead to cirrhosis, hepatic failure and even hepatocellular carcinoma (HCC). Autophagy has attracted much attention because of its controversial role in the course of hepatic fibrosis. In this review, we introduce the mechanism related to noncoding RNAs and some of the signaling pathways that promote or inhibit fibrosis by affecting autophagy. Finally, we list some targets related to autophagy that enable hepatic fibrosis therapy and forecast its prospect in hepatic fibrosis. This review will provide new ideas in diagnosing and treating hepatic fibrosis, which will be helpful to reduce the incidence of cirrhosis and its complications.
摘要
肝纤维化是一种慢性肝损伤过程，其持续发展可导致肝硬化、肝衰竭甚至肝细胞癌（HCC）。自噬因其在肝纤维化过程中的争议性作用而备受关注。在本综述中，我们介绍了与非编码RNA相关的机制以及一些通过影响自噬促进或抑制纤维化的信号通路。最后，我们列出了一些与自噬相关的靶点，这些靶点可用于肝纤维化治疗，并对其在肝纤维化中的前景进行了预测。本综述将为肝纤维化的诊断和治疗提供新思路，有助于降低肝硬化及其并发症的发生率。
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