宫颈癌患者血清肿瘤坏死因子（TNF-α）及可溶性白细胞介素-2受体（SIL 2R）水平的变化及其临床意义。
Changes of serum levels of tumor necrosis factor (TNF-α) and soluble interleukin-2 receptor (SIL 2R) in patients with cervical cancer and their clinical significance.
作者信息
Sha Jing, Du Jing, Yang Jianhong, Hu Xueliang, Li Li
机构信息
Gynceology Department of Xinjiang Preduction and Construction Corps Hospital Urumqi, Xinjiang, China.
Department of Physiology, Preclinical Medicine College, Xinjiang Medical University Urumuqi, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):6599-6604. eCollection 2021.
OBJECTIVE
The goal of the current trial was to investigate the expression levels of tumor necrosis factor-α (TNF-α) and soluble interleukin-2 receptor (SIL-2R) in serum of patients with cervical cancer and analyze their clinical significance.
METHODS
We randomly selected 50 cases of cervical cancer patients who came to our hospital from March 2018 to March 2020 as the experimental group and 50 cases of healthy adult women during the same period as the control group. The experimental group received laparoscopic radical hysterectomy. We compared two groups of patients' serum level of TNF-α and SIL-2R expression. The receiver operating characteristic (ROC) curve was used to determine the diagnostic efficacy of serum TNF-α and SIL-2R in cervical cancer.
RESULTS
The expression levels of serum TNF-α and SIL-2R in the experimental group before radical hysterectomy were significantly higher than that one week after surgery; the preoperative serum TNF-α and SIL-2R expression levels of the experimental group were notably higher than those of the control group; and no marked difference in the expression levels of serum TNF-α and SIL-2R was observed between the control group and the experimental group one week after operation. The area under the curve of TNF-α was 0.846 (95% CI: 0.6050.978), the diagnostic sensitivity was 81.54%, and the specificity was 70.12%; The area under the curve of SIL-2R is 0.813 (95% CI: 0.6010.943), the diagnostic sensitivity was 80.13%, and the specificity was 69.97%.
CONCLUSION
Serum levels of TNF-α and SIL-2R expression in patients with cervical cancer are usually noticeably elevated. After surgical treatment, the serum levels of TNF-α and SIL-2R expression will gradually become normal. It is of significant clinical relevance to detect the serum levels of TNF-α and SIL-2R expression for early diagnosis of intervention of cervical cancer.
目的
本试验旨在研究宫颈癌患者血清中肿瘤坏死因子-α（TNF-α）和可溶性白细胞介素-2受体（SIL-2R）的表达水平，并分析其临床意义。
方法
随机选取2018年3月至2020年3月来我院就诊的50例宫颈癌患者作为试验组，同期选取50例健康成年女性作为对照组。试验组接受腹腔镜根治性子宫切除术。比较两组患者血清TNF-α和SIL-2R表达水平。采用受试者工作特征（ROC）曲线确定血清TNF-α和SIL-2R对宫颈癌的诊断效能。
结果
试验组根治性子宫切除术前血清TNF-α和SIL-2R表达水平显著高于术后1周；试验组术前血清TNF-α和SIL-2R表达水平显著高于对照组；术后1周对照组和试验组血清TNF-α和SIL-2R表达水平无明显差异。TNF-α曲线下面积为0.846（95%CI：0.6050.978），诊断敏感性为81.54%，特异性为70.12%；SIL-2R曲线下面积为0.813（95%CI：0.6010.943），诊断敏感性为80.13%，特异性为69.97%。
结论
宫颈癌患者血清TNF-α和SIL-2R表达水平通常明显升高。手术治疗后，血清TNF-α和SIL-2R表达水平会逐渐恢复正常。检测血清TNF-α和SIL-2R表达水平对宫颈癌的早期诊断干预具有重要临床意义。
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