TRPV5和骨桥蛋白生物标志物水平在早期尿路结石患者临床诊断中的意义
Significance of TRPV5 and OPN biomarker levels in clinical diagnosis of patients with early urinary calculi.
作者信息
Wu Jingzhang, Zhao Jinjin, Zhao Zhenwei, Jin Shanshan, Yu Qian
机构信息
Department of Urology Surgery, Hengshui People's Hospital Hengshui, China.
Department of Anesthesiology, Hengshui People's Hospital Hengshui, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):6778-6783. eCollection 2021.
OBJECTIVE
To investigate the clinical significance of the expression levels of transient receptor potential vanilloid 5 (TRPV5) and Osteopontin (OPN) biomarkers for the diagnosis of early-stage urinary stones.
METHODS
A total of 48 calcium-containing kidney stone patients admitted to our hospital between February 2018 and February 2019 were selected as the experimental group in this study, and another 48 age-matched stone-free healthy individuals were selected as the control group, and the expression levels of TRPV5 and OPN biomarkers in the two groups were examined and compared with respect to related indicators.
RESULTS
The urine oxalic acid content of the experimental group was found to be notably higher than the control group, while the citric acid content was lower; we observed higher levels of the 24-hour urine calcium content in the experimental group, while the citric acid/calcium ratio was remarkably lower; 24-hour urine magnesium and phosphorus levels of the two groups showed no marked difference; the mRNA expression levels of TRPV5 and OPN in the kidney tissues of the two groups were statistically different.
CONCLUSION
The level of TRPV5 in urinary calculi patients was found to be significantly lower, whereas the level of OPN was significantly higher than the normal control, thus TRPV5 and OPN biomarker levels can be used as diagnostic markers for early urinary calculi.
目的
探讨瞬时受体电位香草酸亚型5（TRPV5）和骨桥蛋白（OPN）生物标志物表达水平对早期尿路结石诊断的临床意义。
方法
选取2018年2月至2019年2月我院收治的48例含钙肾结石患者作为实验组，另选取48例年龄匹配的无结石健康个体作为对照组，检测两组中TRPV5和OPN生物标志物的表达水平，并比较相关指标。
结果
发现实验组尿草酸含量显著高于对照组，而柠檬酸含量较低；观察到实验组24小时尿钙含量较高，而柠檬酸/钙比值显著较低；两组24小时尿镁和磷水平无明显差异；两组肾组织中TRPV5和OPN的mRNA表达水平存在统计学差异。
结论
发现尿路结石患者的TRPV5水平显著低于正常对照组，而OPN水平显著高于正常对照组，因此TRPV5和OPN生物标志物水平可作为早期尿路结石的诊断标志物。
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