糖皮质激素与特布他林治疗慢性阻塞性肺疾病急性加重期的临床疗效
Clinical efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.
作者信息
Li Yan, Xu Zhi, Qing Cuo, Zhang Hong, Wu Xia, Yang Jilu
机构信息
Department of Respiratory and Critical Care Medicine, The 3rd Affiliated Hospital of Chengdu Medical College Chengdu 611700, Sichuang Province, China.
Pidu District People's Hospital Chengdu 611700, Sichuang Province, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):7029-7034. eCollection 2021.
BACKGROUND
To investigate the efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
METHODS
248 patients with AECOPD were assigned into two groups, 124 patients in the control group were only given terbutaline treatment, while 124 patients in the experimental group were treated with glucocorticoid and terbutaline. The effect on lung function and blood gas indexes were compared between the two groups.
RESULTS
The total effective rate of the treatment with glucocorticoid and terbutaline was higher than that of control group (P < 0.05). After treatment, the pulmonary function indexes such as FEV, FVC and PaO levels in the two groups were significantly higher than those before treatment, PaCO levels were significantly lower than that before the treatment (P < 0.05).
CONCLUSIONS
The combined use of glucocorticoid and terbutaline could effectively improve the lung function and blood gas indexes. It's of great significance to promote the rehabilitation of patients with AECOPD, and it provides insights for future clinical practice.
背景
探讨糖皮质激素与特布他林治疗慢性阻塞性肺疾病急性加重期（AECOPD）的疗效。
方法
将248例AECOPD患者分为两组，对照组124例仅给予特布他林治疗，实验组124例给予糖皮质激素与特布他林治疗。比较两组对肺功能及血气指标的影响。
结果
糖皮质激素与特布他林联合治疗的总有效率高于对照组（P < 0.05）。治疗后，两组的肺功能指标如第一秒用力呼气容积（FEV）、用力肺活量（FVC）及动脉血氧分压（PaO）水平均显著高于治疗前，动脉血二氧化碳分压（PaCO）水平显著低于治疗前（P < 0.05）。
结论
糖皮质激素与特布他林联合使用可有效改善肺功能及血气指标。对促进AECOPD患者康复具有重要意义，为今后的临床实践提供了思路。
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