Ezzatt Ola M, Hamed Mohamed G, Gamil Yasmine
Associate professor in department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Assistant professor in department of Otorhinolaryngology, Faculty of Medicine, Helwan University and ENT consultant in Arayah Hospital in Maadi, Cairo, Egypt.
J Clin Exp Dent. 2021 Jul 1;13(7):e701-e708. doi: 10.4317/jced.58292. eCollection 2021 Jul.
The study aimed to assess oropharyngeal and otorhinolaryngological changes in end stage renal disease (ESRD) patients undergoing hemodialysis and correlate the findings to renal functions.
This case-control study compared oral and otorhinolaryngological findings in 85 patients with (ESRD) on maintenance hemodialysis to age and sex matched 85 healthy controls. Frequencies of findings were calculated and compared and correlation between biochemical and the oral health parameters in case group was determined using T-test, chi-square and Pearson correlation test (significance were set at <0.05).
The frequency of oral signs and mucosal symptoms were significantly higher among ESRD compared to healthy controls. Dry mouth (34.12%), bad odour (32.94%), increased tongue coating (50.59%) and pale mucosa (45.88%) were the most commonly reported. Otorhinolaryngological findings was higher in cases than in controls, with otomycosis (10.59%) and allergic rhinitis (5.88%) being the most frequent findings. Serum creatinine and blood urea mean levels were higher in ESRD patients with oral and otorhinolaryngological findings compared to those without findings.
Oral and nasal manifestations in patients with ESRD on maintenance hemodialysis were significantly higher in comparison to healthy individuals and were related to their serum creatinine and blood urea mean levels. Chronic kidney disease, renal dialysis, Oral manifestation, nasal, case control, Egypt.
本研究旨在评估接受血液透析的终末期肾病（ESRD）患者的口咽及耳鼻咽喉变化，并将结果与肾功能相关联。
本病例对照研究比较了85例接受维持性血液透析的ESRD患者与85例年龄和性别匹配的健康对照者的口腔及耳鼻咽喉检查结果。计算并比较了各项检查结果的频率，并使用t检验、卡方检验和Pearson相关检验确定病例组生化指标与口腔健康参数之间的相关性（显著性设定为<0.05）。
与健康对照者相比，ESRD患者的口腔体征和黏膜症状发生率显著更高。最常报告的有口干（34.12%）、口臭（32.94%）、舌苔增厚（50.59%）和黏膜苍白（45.88%）。病例组的耳鼻咽喉检查结果高于对照组，最常见的是耳霉菌病（10.59%）和过敏性鼻炎（5.88%）。有口腔及耳鼻咽喉检查结果的ESRD患者血清肌酐和血尿素平均水平高于无相关结果的患者。
与健康个体相比，接受维持性血液透析的ESRD患者的口腔和鼻腔表现显著更高，且与他们的血清肌酐和血尿素平均水平相关。慢性肾病、肾透析、口腔表现、鼻腔、病例对照、埃及。
