氰化物中毒的治疗问题

Therapeutic problems in cyanide poisoning.

作者信息

van Heijst A N, Douze J M, van Kesteren R G, van Bergen J E, van Dijk A

机构信息

Department of Reanimation and Clinical Toxicology, State University Hospital, Utrecht, The Netherlands.

出版信息

J Toxicol Clin Toxicol. 1987;25(5):383-98. doi: 10.3109/15563658708992641.

DOI:10.3109/15563658708992641

PMID:3430655

Abstract

In three patients with severe acute cyanide poisoning, a cyanosis was observed instead of the bright pink skin coloration often mentioned as a sign in textbooks. Treatment of cardiopulmonary insufficiency is as essential as antidotal therapy and the use of sodium nitrite and 4-DMAP is not without risk as, in practice, the methemoglobin-level induced is difficult to control.

摘要

在三名严重急性氰化物中毒患者中，观察到的是发绀，而非教科书上常提及的作为体征的皮肤亮粉色。治疗心肺功能不全与解毒治疗同样重要，并且使用亚硝酸钠和4-二甲基氨基苯酚并非毫无风险，因为在实际操作中，所诱导的高铁血红蛋白水平难以控制。