Obese Ernest, Ameyaw Elvis Ofori, Biney Robert Peter, Adakudugu Emmanuel Awintiig, Woode Eric
School of Pharmacy and Pharmaceutical Sciences, College of Health & Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Department of Pharmacology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Scientifica (Cairo). 2021 Jul 1;2021:5551380. doi: 10.1155/2021/5551380. eCollection 2021.
has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated.
Irwin's test was performed to determine the effect of the oral administration of the extract (30-3000 mg kg) on gross behaviour and physiological function. The activity meter, rotarod, pentylenetetrazol- (PTZ-) induced convulsion, pentobarbitone-induced sleep test, and the tail immersion tests were used to evaluate the spontaneous activity, neuromuscular function, convulsive threshold, sedation, and analgesic effects of the extract (30-1000 mg/kg), respectively, in mice.
extract (CPE) exhibited significant ( < 0.0001) anticonvulsant and analgesic effects. There was a significant increase in withdrawal latency of the CPE-treated animals in the tail immersion test for analgesia ( < 0.0001), while latency and duration of PTZ-induced convulsions were positively modulated. extract showed significant ( < 0.0001) central nervous system depressant effects in pentobarbitone-induced hypnosis at 100-1000 mg/kg and spontaneous activity test (30-1000 mg/kg). The extract also depicted impaired motor coordination at 100-1000 mg/kg dose levels. LD was estimated to be above 1000 mg kg.
extract has significant central nervous system depressant and analgesic effects in mice.
传统上因其镇痛和抗炎作用而被广泛使用。据报道，即使在缺乏科学数据支持的情况下，它在民族医学中也被用于治疗包括癫痫在内的精神健康障碍。因此，评估了该植物影响神经功能的潜力。
进行欧文氏试验以确定口服提取物（30 - 3000毫克/千克）对总体行为和生理功能的影响。活动计、转棒试验、戊四氮（PTZ）诱导惊厥试验、戊巴比妥诱导睡眠试验以及尾浸试验分别用于评估提取物（30 - 1000毫克/千克）对小鼠的自发活动、神经肌肉功能、惊厥阈值、镇静和镇痛作用。
提取物（CPE）表现出显著（P < 0.0001）的抗惊厥和镇痛作用。在镇痛的尾浸试验中，CPE处理的动物的撤药潜伏期显著增加（P < 0.0001），而PTZ诱导惊厥的潜伏期和持续时间得到正向调节。提取物在100 - 1000毫克/千克的戊巴比妥诱导催眠试验和自发活动试验（30 - 1000毫克/千克）中表现出显著（P < 0.0001）的中枢神经系统抑制作用。提取物在100 -
