Instituto Superior de Biomedicina. Universidade Estadual do Ceará, Ceará, Brazil.
Epilepsy Behav. 2012 Feb;23(2):123-6. doi: 10.1016/j.yebeh.2011.11.008. Epub 2012 Jan 9.
Calotropis procera (Ait.) R.Br. is a laticiferous plant belonging to the Apocynaceae family. C. procera latex proteins were evaluated with respect to anticonvulsant and sedative activity in mouse models of pentylenetetrazol (PTZ)-, pilocarpine-, and strychnine-induced convulsions or turning behavior and pentobarbital-induced sleep. In the strychnine- and pilocarpine-induced seizure models, C. procera latex proteins caused no significant alterations in latencies to convulsions and death, as compared with controls. In the PTZ-induced seizure model, administration of C. procera latex proteins in high doses (50 or 100mg/kg) and diazepam caused significant increases in latencies to convulsions and death. C. procera latex proteins (50 or 100mg/kg) and 2mg/kg diazepam caused a decrease in sleep latency and an increase in sleep time compared with the control group and groups treated with 5 or 10mg/kg. Our results suggest that C. procera latex proteins have a central nervous system-depressant activity as reflected in their potentiation of pentobarbital-induced sleeping time and their anticonvulsant action in the PTZ-induced seizure model.
美丽鹰萝是夹竹桃科的乳汁植物。研究了美丽鹰萝乳汁蛋白的抗惊劂和镇静活性。在戊四氮（PTZ）、毛果芸香碱和士的宁诱发的惊劂或转动行为以及戊巴比妥钠诱发的睡眠的小鼠模型中评价了美丽鹰萝乳汁蛋白的活性。与对照组相比，在士的宁和毛果芸香碱诱发的惊劂模型中，美丽鹰萝乳汁蛋白对惊劂潜伏期和死亡无显著改变。在 PTZ 诱发的惊劂模型中，给予美丽鹰萝乳汁蛋白高剂量（50 或 100mg/kg）和地西泮显著增加惊劂潜伏期和死亡。与对照组和用 5 或 10mg/kg 治疗的组相比，美丽鹰萝乳汁蛋白（50 或 100mg/kg）和 2mg/kg 地西泮降低了睡眠潜伏期并增加了睡眠时间。我们的结果表明，美丽鹰萝乳汁蛋白具有中枢神经系统抑制活性，表现在增强戊巴比妥钠诱导的睡眠时间和在 PTZ 诱发的惊劂模型中的抗惊劂作用。
