减少A组链球菌简单感染的广谱抗生素治疗以降低对微生物群的损害。
Reducing Broad-Spectrum Antibiotic Treatment of Simple Group A Streptococcal Infections to Reduce Harm to the Microbiome.
作者信息
Sumibcay Tyrone J, Lee-Jayaram Jannet J, Yamamoto Loren G
机构信息
Pediatrics, Kapi`olani Medical Center for Women & Children, Honolulu, USA.
Pediatric Emergency Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, USA.
出版信息
Cureus. 2021 Jun 13;13(6):e15629. doi: 10.7759/cureus.15629. eCollection 2021 Jun.
Background Broad-spectrum antibiotics disrupt the human microbiome resulting in a greater risk of harmful, long-term conditions that impact human health. Group A streptococcal (GAS) infections can be treated with penicillin. Objective We examined the treatment of simple GAS infections to assess the use of broad-spectrum antibiotics. Methods Smart relational database extraction queries from January 1, 2016 to July 10, 2019 (3.6 years) of patients less than 22 years old in a 4-hospital system electronic medical record (EMR). Results We found 1778 non-ED outpatients and 873 ED patients with simple GAS infections who were not allergic to penicillin. A total of 75% and 44% of non-ED and ED patients were treated with broad-spectrum antibiotics, respectively (p < 0.001). Older patients were treated with penicillin alone more frequently than younger age groups (p < 0.001). Conclusion These findings highlight opportunities for clinicians to reduce the utilization of broad-spectrum antibiotics for the treatment of simple GAS infections to reduce harm to the microbiome.
背景
广谱抗生素会破坏人类微生物群，导致出现更多影响人类健康的有害长期病症的风险。A组链球菌（GAS）感染可用青霉素治疗。目的：我们研究了单纯性GAS感染的治疗方法，以评估广谱抗生素的使用情况。方法：从2016年1月1日至2019年7月10日（3.6年），在一个4家医院系统的电子病历（EMR）中，对年龄小于22岁的患者进行智能关系数据库提取查询。结果：我们发现1778例非急诊门诊患者和873例单纯性GAS感染且对青霉素不过敏的急诊患者。非急诊和急诊患者分别有75%和44%接受了广谱抗生素治疗（p<0.001）。老年患者比年轻患者更频繁地单独使用青霉素治疗（p<0.001）。结论：这些发现凸显了临床医生减少使用广谱抗生素治疗单纯性GAS感染的机会，以减少对微生物群的损害。
Zotero 插件