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阿维鲁单抗维持治疗的弥漫性肺泡出血

Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy.

作者信息

Li Si, Sharma Nishant, Kazmierski Daniel, Amjad Mohammad Asim, Dong Yishan, Wang Yichen, Sharma Namita, Ramakrishna Srinivasarao, Ochieng Pius

机构信息

Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, USA.

Internal Medicine, Rochester Regional Health, Rochester General Hospital, Rochester, USA.

出版信息

Cureus. 2021 Jun 21;13(6):e15805. doi: 10.7759/cureus.15805. eCollection 2021 Jun.

DOI:10.7759/cureus.15805
PMID:34306873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8294017/
Abstract

Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by the COVID-19 pandemic. We report a case of a patient with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage (DAH) following treatment with avelumab.

摘要

免疫检查点阻断是肿瘤学中一种迅速发展的治疗方式。然而，其不良反应超出了传统化疗的细胞毒性。与免疫检查点治疗相关的肺毒性带来了诊断难题，而新型冠状病毒肺炎大流行使这一难题更加复杂。我们报告一例转移性尿路上皮癌患者，在接受阿维鲁单抗治疗后发生弥漫性肺泡出血（DAH）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9b/8294017/913d8ea6ef5e/cureus-0013-00000015805-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9b/8294017/15d92716ae7c/cureus-0013-00000015805-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9b/8294017/913d8ea6ef5e/cureus-0013-00000015805-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9b/8294017/15d92716ae7c/cureus-0013-00000015805-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9b/8294017/913d8ea6ef5e/cureus-0013-00000015805-i02.jpg

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Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy.阿维鲁单抗维持治疗的弥漫性肺泡出血
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Durvalumab-Induced Diffuse Alveolar Hemorrhage: An Autopsy Case Report.度伐利尤单抗诱导的弥漫性肺泡出血：一例尸检病例报告
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引用本文的文献

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Response and Outcomes of Maintenance Avelumab After Platinum-Based Chemotherapy (PBC) in Patients With Advanced Urothelial Carcinoma (aUC): "Real World" Experience.晚期尿路上皮癌（aUC）患者在铂类化疗（PBC）后使用avelumab 维持治疗的反应和结局：“真实世界”经验。
Clin Genitourin Cancer. 2023 Oct;21(5):584-593. doi: 10.1016/j.clgc.2023.06.008. Epub 2023 Jun 20.
2
Isolated Renal Calyceal Urothelial Carcinoma Effectively Treated With PD-1 Inhibitor Alone: A Case Report And Literature Review.单独使用PD-1抑制剂有效治疗孤立性肾盏尿路上皮癌：一例报告及文献综述
Front Oncol. 2022 May 10;12:866013. doi: 10.3389/fonc.2022.866013. eCollection 2022.

本文引用的文献

1
Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.阿维鲁单抗维持治疗晚期或转移性尿路上皮癌。
N Engl J Med. 2020 Sep 24;383(13):1218-1230. doi: 10.1056/NEJMoa2002788. Epub 2020 Sep 18.
2
Durvalumab-Induced Diffuse Alveolar Hemorrhage: An Autopsy Case Report.度伐利尤单抗诱导的弥漫性肺泡出血：一例尸检病例报告
Case Rep Oncol. 2020 Jun 22;13(2):696-701. doi: 10.1159/000507848. eCollection 2020 May-Aug.
3
Diffuse alveolar hemorrhage with nivolumab monotherapy.纳武单抗单药治疗导致的弥漫性肺泡出血。
Respir Med Case Rep. 2020 Jun 11;30:101131. doi: 10.1016/j.rmcr.2020.101131. eCollection 2020.
4
A case of interstitial lung disease with alveolar hemorrhage induced by pembrolizumab.1例由帕博利珠单抗引起的间质性肺疾病伴肺泡出血。
Onco Targets Ther. 2018 Sep 17;11:5879-5883. doi: 10.2147/OTT.S169321. eCollection 2018.
5
Diffuse alveolar hemorrhage with pseudoprogression during nivolumab therapy in a patient with malignant melanoma.在接受纳武利尤单抗治疗的恶性黑色素瘤患者中出现弥漫性肺泡出血伴假性进展。
Thorac Cancer. 2018 Nov;9(11):1522-1524. doi: 10.1111/1759-7714.12872. Epub 2018 Sep 25.
6
Goodpasture's disease in a patient with advanced lung cancer treated with nivolumab: An autopsy case report.在接受纳武利尤单抗治疗的晚期肺癌患者中发生 Goodpasture 病：一例尸检病例报告。
Lung Cancer. 2018 Aug;122:22-24. doi: 10.1016/j.lungcan.2018.05.015. Epub 2018 May 19.
7
Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials.avelumab 在晚期实体瘤患者中的安全性特征：来自 JAVELIN 实体瘤 1 期和 JAVELIN Merkel 200 期临床试验数据的汇总分析。
Cancer. 2018 May 1;124(9):2010-2017. doi: 10.1002/cncr.31293. Epub 2018 Feb 22.
8
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.与免疫检查点阻断相关的免疫相关不良事件。
N Engl J Med. 2018 Jan 11;378(2):158-168. doi: 10.1056/NEJMra1703481.
9
Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial.阿维鲁单抗用于治疗转移性或局部晚期经治实体瘤（JAVELIN实体瘤研究）：一项1a期、多队列、剂量递增试验
Lancet Oncol. 2017 May;18(5):587-598. doi: 10.1016/S1470-2045(17)30239-5. Epub 2017 Mar 31.
10
PD-1 and PD-L1 antibodies in cancer: current status and future directions.癌症中的PD-1和PD-L1抗体：现状与未来方向。
Cancer Immunol Immunother. 2017 May;66(5):551-564. doi: 10.1007/s00262-017-1954-6. Epub 2017 Feb 17.