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前庭神经鞘瘤手术后的硬脑膜静脉窦血栓形成:抗凝困境

Dural Venous Sinus Thrombosis after Vestibular Schwannoma Surgery: The Anticoagulation Dilemma.

作者信息

Brahimaj Bledi C, Beer-Furlan Andre, Crawford Fred, Nunna Ravi, Urban Matthew, Wu Gary, Abello Eric, Chauhan Vikrant, Kocak Mehmet, Muñoz Lorenzo, Wiet Richard M, Byrne Richard W

机构信息

Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, United States.

Rush University College of Medicine, Chicago, Illinois, United States.

出版信息

J Neurol Surg B Skull Base. 2021 Jul;82(Suppl 3):e3-e8. doi: 10.1055/s-0039-3400296. Epub 2019 Nov 21.

Abstract

Dural venous sinus thrombosis (DVST) is a relatively understudied complication of vestibular schwannoma (VS) surgery. Several studies have examined this topic; however, there is limited data on the incidence, clinical progression, and proper management of this patient population.  A retrospective review was performed for patients undergoing surgery for VS at a single institution. All postoperative imaging was reviewed for incidence of DVST. Demographic data were collected including tumor and surgical characteristics along with postoperative course.  A total of 63 patients underwent resection of their VS. The incidence of DVST was 34.9%. The operative time was greater in the dural venous sinus thrombosis (DSVT) group, at an average of 6.69 hours versus 4.87 in the no DSVT cohort (  = 0.04). Tumor size was correlationally significant (  = 0.051) at 2.75 versus 2.12 cm greatest diameter. The translabyrinthine approach was most prevalent (68.2%). The side of the thrombosis was ipsilateral to the tumor and surgery in all patients. The sigmoid sinus was most commonly involved (95.5%). Of them, 85% patients had a codominant or thrombus contralateral to the dominant sinus. All patients were asymptomatic. No patients were treated with anticoagulation. Resolution of thrombus was seen in five (22.7%) of the patients on last follow-up imaging. There were no hemorrhagic complications.  The overall incidence of DVST was (34.9%) of 63 patients who underwent VS surgery. All patients were asymptomatic and none were treated with anticoagulation. In our study, continuing to observe asymptomatic patients did not lead to any adverse events.

摘要

硬脑膜静脉窦血栓形成(DVST)是前庭神经鞘瘤(VS)手术中一个研究相对较少的并发症。已有多项研究探讨了这一主题;然而,关于该患者群体的发病率、临床进展和恰当管理的数据有限。

对在单一机构接受VS手术的患者进行了一项回顾性研究。对所有术后影像进行审查以确定DVST的发生率。收集了人口统计学数据,包括肿瘤和手术特征以及术后病程。

共有63例患者接受了VS切除术。DVST的发生率为34.9%。硬脑膜静脉窦血栓形成(DSVT)组的手术时间更长,平均为6.69小时,而无DSVT队列的平均手术时间为4.87小时(P = 0.04)。肿瘤大小具有显著相关性(P = 0.051),最大直径分别为2.75 cm和2.12 cm。经迷路入路最为常见(68.2%)。所有患者血栓形成的一侧均与肿瘤及手术同侧。乙状窦最常受累(95.5%)。其中,85%的患者在优势窦对侧有并存血栓或血栓形成。所有患者均无症状。没有患者接受抗凝治疗。在最后一次随访影像检查中,5例(22.7%)患者的血栓消失。没有出血性并发症。

在接受VS手术的63例患者中,DVST的总体发生率为34.9%。所有患者均无症状,且无一接受抗凝治疗。在我们的研究中,持续观察无症状患者未导致任何不良事件。

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