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乙状窦血栓形成后切除前庭神经鞘瘤采用枕下入路后颅窝 approach-thrombosis 分类和管理建议。

Dural sinus thrombosis after resection of vestibular schwannoma using suboccipital retrosigmoid approach-thrombosis classification and management proposal.

机构信息

Department of Neurosurgery and Neurooncology, Copernicus Memorial Hospital, Pabianicka 62, 95-513, Łódź, Poland.

Department of Neurosurgery, 10th Military Research Hospital, Bydgoszcz, Poland.

出版信息

Neurosurg Rev. 2022 Jun;45(3):2211-2219. doi: 10.1007/s10143-022-01741-3. Epub 2022 Jan 21.

Abstract

Dural sinus thrombosis is one of the complications after posterior fossa surgery. However, that topic is not described well with regard to vestibular schwannoma surgery using the unique suboccipital retrosigmoid approach. We analyzed retrospectively medical records and radiological investigations of 116 patients. The including criteria were histopathologically confirmed vestibular schwannoma operated on using the retrosigmoid approach, preoperative and postoperative contrast-enhanced MRI, and at least 1-year follow-up. The patient group included 36% males and 64% females. The average age was 47.3 ± 13.9 years. Sixty percent of the tumors were classified as T4b according to the Hannover scale and their mean volume was 13.73 ± 10.28 cm. There were no signs of thrombosis preoperatively. Postoperative changes in the dural sinuses were found in 26 (22%) cases. In 7 (27%) cases, there was an external compression by the hemostatic agent, and in 19 (73%) cases, a thrombus was visualized in the sinus lumen. The size of the sinus, age, and the tumor size were not risk factors for thrombosis, whereas an intraoperative sinus injury was a statistically significant risk factor (p = 0.0012). All of the patients diagnosed with thrombosis were in good clinical condition in long-term follow-up, except one fatal case. Complete recanalization was observed in 58% of cases after 1-year follow-up. Postoperative changes in the dural venous sinuses are a frequent finding after vestibular schwannoma surgery using the suboccipital retrosigmoid approach. Intraoperative dural injury is a risk factor for thrombosis. Thrombosis in that group of patients is usually asymptomatic and does not influence the prognosis.

摘要

硬脑膜窦血栓形成是后颅窝手术后的并发症之一。然而,在后颅窝乙状窦后入路切除前庭神经鞘瘤手术中,该问题并没有得到很好的描述。我们回顾性分析了 116 例患者的病历和影像学资料。纳入标准为:经病理证实为前庭神经鞘瘤,采用乙状窦后入路手术,术前和术后增强磁共振成像,随访时间至少 1 年。患者组包括 36%的男性和 64%的女性。平均年龄为 47.3±13.9 岁。根据汉诺威分级,60%的肿瘤为 T4b 级,平均体积为 13.73±10.28cm。术前无血栓形成迹象。26 例(22%)术后硬脑膜窦发生变化。7 例(27%)可见止血剂外部压迫,19 例(73%)窦腔内可见血栓。窦大小、年龄和肿瘤大小不是血栓形成的危险因素,而术中窦损伤是一个统计学上显著的危险因素(p=0.0012)。所有诊断为血栓形成的患者在长期随访中临床状况良好,除 1 例死亡。1 年后随访,58%的患者完全再通。乙状窦后入路切除前庭神经鞘瘤术后硬脑膜静脉窦改变是一种常见现象。术中硬脑膜损伤是血栓形成的危险因素。该组患者的血栓形成通常无症状,不影响预后。

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