Translabyrinthine Craniotomy Is Associated with Higher Risk of Asymptomatic Dural Venous Sinus Thrombosis in Vestibular Schwannoma Resection.

OBJECTIVE

Characterize the incidence, risk factors, and patient outcomes of dural venous sinus thrombosis identified on postoperative imaging after retrosigmoid or translabyrinthine craniotomy for vestibular schwannoma resection.

STUDY DESIGN

Retrospective cohort study.

SETTING

Single tertiary academic referral center.

PATIENTS

Eighty-one patients 19 to 82 years of age with vestibular schwannomas, 58% female.

INTERVENTIONS

Retrosigmoid or translabyrinthine craniotomy with postoperative magnetic resonance imaging/magnetic resonance venography.

MAIN OUTCOME MEASURES

Association between operative approach, age, sex, body mass index, tumor size, dominant sinus, operative time, laterality, and perioperative cerebrospinal fluid (CSF) leaks with rate of thrombosis.

RESULTS

Translabyrinthine craniotomy was associated with the highest relative risk of thrombosis (odds ratios [OR] = 19.82, 95% confidence interval [CI] = 1.75-224, p = 0.007), followed by male sex (OR = 5.53, 95% CI = 1.63-18.8, p = 0.035). Other patient and demographic risk factors were not associated with increased rates of dural venous thrombosis, nor was there an association with postoperative CSF leak. 81% (25/31) of thrombi had resolved within 3 years of surgery.

CONCLUSIONS

Translabyrinthine approach and male sex most strongly predicted postoperative dural venous thrombosis after postauricular craniotomy for vestibular schwannoma resection.

PROFESSIONAL PRACTICE GAP AND EDUCATIONAL NEED

Better understanding of risk factors and management of dural venous thrombosis after vestibular schwannoma surgery.

LEARNING OBJECTIVE

Characterize clinically significant risk factors for dural venous thrombosis in vestibular schwannoma surgery.

DESIRED RESULT

Identification of patient and operative risk factors for dural venous thrombosis.

LEVEL OF EVIDENCE

III.

INDICATE IRB OR IACUC

Exempt.