Renye John A, Steinberg Dennis H
Dairy and Functional Foods Research Unit, Agricultural Research Service, USDA, 600 E. Mermaid Lane, Wyndmoor, PA 19038.
Biotechnol Rep (Amst). 2021 Jun 16;31:e00647. doi: 10.1016/j.btre.2021.e00647. eCollection 2021 Sep.
Dental caries continues to occur in both children and adults worldwide resulting in significant economic burden, and consumers have expressed interest in natural products that can prevent these recurrent infections. In this study, B59671, which produces thermophilin 110, was shown to inhibit the growth of UA159. A thermophilin concentration ≥ 80 AU ml prevented the growth of UA159 in batch culture, while ≥ 160 AU ml was required to prevent biofilm growth. Co-culturing B59671 and UA159 also resulted in impaired biofilm growth. Thermophillin 110 was also shown inhibit additional strains and commensal oral streptococci at higher concentrations (640-1280 AU ml). These results suggest that thermophilin 110 could be used as a natural antimicrobial in oral care products and support the need for additional studies to assess the probiotic potential of B59671.
全球范围内,龋齿在儿童和成人中持续出现,造成了巨大的经济负担,消费者对能够预防这些复发性感染的天然产品表现出兴趣。在本研究中,产嗜热菌素110的B59671被证明可抑制UA159的生长。嗜热菌素浓度≥80 AU/ml可在分批培养中阻止UA159的生长,而阻止生物膜生长则需要≥160 AU/ml。将B59671与UA159共培养也会导致生物膜生长受损。嗜热菌素110在较高浓度(640 - 1280 AU/ml)时还可抑制其他菌株和口腔共生链球菌。这些结果表明,嗜热菌素110可作为口腔护理产品中的天然抗菌剂,并支持开展更多研究以评估B59671的益生菌潜力。