Okada T, Furukawa S
Department of Pediatrics, Kagawa Children Hospital.
Jpn J Antibiot. 1987 Aug;40(8):1477-85.
The transfer to cerebrospinal fluid of a new oxacephem antibiotic flomoxef (FMOX, 6315-S) and its clinical efficacy against bacterial infections were investigated. 1. In 3 cases of purulent meningitis, cerebrospinal fluid concentrations of FMOX after one shot intravenous injection of 100 mg/kg during the acute stage of infections were 5.12-6.32 micrograms/ml and ratios of FMOX in cerebrospinal fluid in serum were about 5%. During the recovery stage, cerebrospinal fluid concentrations were about 3.8 micrograms/ml and cerebrospinal fluid/serum ratios were about 3.5%. 2. In 1 case of purulent meningitis, the treatment with FMOX was clinically effective but this case was classified as "unevaluable" because other drug was used concomitantly. FMOX was rated effective in other 2 cases of purulent meningitis. Of 9 cases of pneumonia, FMOX was rated very effective in 8 cases and it was rated only effective in the other. Of 4 cases of bronchitis, the drug was rated very effective in 3 cases and only effective in the other. FMOX was rated very effective against 2 cases of tonsillitis, also. 3. As side effects, thrombocytosis was observed in 3 of 20 cases examined. All cases, however, were deemed unrelated to the FMOX treatment and the side effect was only transient as are often found in courses of recovery from infections.
对新型氧头孢烯类抗生素氟氧头孢（FMOX，6315 - S）向脑脊液中的转移情况及其对细菌感染的临床疗效进行了研究。1. 在3例化脓性脑膜炎患者中，感染急性期静脉注射100mg/kg后，脑脊液中氟氧头孢的浓度为5.12 - 6.32微克/毫升，脑脊液中氟氧头孢与血清中的比例约为5%。在恢复期，脑脊液浓度约为3.8微克/毫升，脑脊液/血清比例约为3.5%。2. 在1例化脓性脑膜炎患者中，氟氧头孢治疗临床有效，但因同时使用了其他药物，该病例被归类为“不可评估”。在其他2例化脓性脑膜炎病例中，氟氧头孢被评为有效。在9例肺炎患者中，氟氧头孢在8例中被评为非常有效，在另一例中仅被评为有效。在4例支气管炎患者中，该药物在3例中被评为非常有效，在另一例中仅被评为有效。氟氧头孢对2例扁桃体炎也被评为非常有效。3. 作为副作用，在20例接受检查的病例中有3例观察到血小板增多。然而，所有病例都被认为与氟氧头孢治疗无关，且这种副作用只是短暂的，在感染恢复过程中经常出现。
